CD274 mRNA binds miR-142-5p RISC

Stable Identifier
R-HSA-9925320
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CD274 mRNA binds miR-142-5p RISC
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MicroRNA-142 (miR-142) plays a crucial role in regulating the development, stability, and function of regulatory T cells. The miR-142-3p variant specifically modulates regulatory T cell balance and immune tolerance by reducing IFNγ responses. Primarily expressed in hematopoietic cells, miR-142 produces two main mature miRNAs, miR-142-5p and miR-142-3p, originating from opposite strands of the miR-142 precursor’s hairpin structure (Wang et al., 2022). miR-142-5p also plays a key role in the regulation of CD274 (PD-L1) expression by targeting 3’UTR of PDL1 mRNA. Using luciferase assays with a CD274 (PD-L1) 3' UTR reporter in pancreatic cancer cell lines (PANC-1) (Jia et al.,2017) and hepatocellular carcinoma (HCC) cell lines (HepG2 and Huh7) (Jiang et al.,2021), it was confirmed reduced reporter activity upon miR0142 mimic transfection. The study demonstrates direct association of miR-142 with PD-L1 mRNA and suppression of PD-L1 expression.
Literature References
PubMed ID Title Journal Year
28511795 miR-142-5p regulates tumor cell PD-L1 expression and enhances anti-tumor immunity

Jia, L, Xi, Q, Wang, H, Zhang, Z, Liu, H, Cheng, Y, Guo, X, Zhang, J, Zhang, Q, Zhang, L, Xue, Z, Li, Y, Da, Y, Zhao, P, Zhang, R

Biochem Biophys Res Commun 2017
34653794 Cancer-associated fibroblasts-derived exosomes promote lung cancer progression by OIP5-AS1/ miR-142-5p/ PD-L1 axis

Jiang, Y, Wang, K, Lu, X, Wang, Y, Chen, J

Mol Immunol 2021
30679789 Correction: Control of PD-L1 expression by miR-140/142/340/383 and oncogenic activation of the OCT4-miR-18a pathway in cervical cancer

Dong, P, Xiong, Y, Yu, J, Chen, L, Tao, T, Yi, S, Hanley, SJB, Yue, J, Watari, H, Sakuragi, N

Oncogene 2019
Participants
Input
Output
Participates
as an event of
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-10-16)
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