CD274 mRNA binds miR-200B/C RISC

Stable Identifier
R-HSA-9925324
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CD274 mRNA binds miR-200B/C RISC
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microRNA-200 family of microRNAs play an important role in T cell function regulation in normal and disease conditions like cancers (Humphries et al., 2015). In the context of PD-L1 expression regulation, microRNA-200b (miR-200b) suppresses the CD274 (PD-L1) translation by directly binding to the 3’UTR of the PDL1 mRNA. Co-transfection of a wild‑type PD‑L1 3’‑UTR luciferase reporter construct and miR‑200b or miR‑200c into murine (344SQ) or human (H157 or H1299) lung cancer cells, which have low endogenous levels of miR‑200, resulted in reduced luciferase reporter activity, demonstrating that PD‑L1 is directly regulated by microRNA‑200 (Chen et al., 2014, Katakura et al., 2020)
Literature References
PubMed ID Title Journal Year
32893980 MicroRNA-200b is a potential biomarker of the expression of PD-L1 in patients with lung cancer

Katakura, S, Kobayashi, N, Hashimoto, H, Kamimaki, C, Tanaka, K, Kubo, S, Nakashima, K, Teranishi, S, Manabe, S, Watanabe, K, Horita, N, Hara, Y, Yamamoto, M, Kudo, M, Piao, H, Kaneko, T

Thorac Cancer 2020
25348003 Metastasis is regulated via microRNA-200/ZEB1 axis control of tumour cell PD-L1 expression and intratumoral immunosuppression

Chen, L, Gibbons, DL, Goswami, S, Cortez, MA, Ahn, YH, Byers, LA, Zhang, X, Yi, X, Dwyer, D, Lin, W, Diao, L, Wang, J, Roybal, J, Patel, M, Ungewiss, C, Peng, D, Antonia, S, Mediavilla-Varela, M, Robertson, G, Suraokar, M, Welsh, JW, Erez, B, Wistuba, II, Chen, L, Peng, D, Wang, S, Ullrich, SE, Heymach, JV, Kurie, JM, Qin, FX

Nat Commun 2014
Participants
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Output
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Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-10-16)
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