CD274 translation

Stable Identifier
R-HSA-9925190
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CD274 translation
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CD274 (PD-L1) translation is a critical step in the regulation of PD-L1 expression. At translational level, PD-L1 is regulated by multiple factors including microRNAs (miRNAs). miRNA can directly regulate translation by targeting 3’ untranslated region (3’UTR) of PD-L1 mRNA and regualtes its expression (Skafi et al. 2020, Wang et al., 2020). Under normal physiological conditions, these miRNAs prevent the over-expression of PDL1, thus helps prevent immune tolerance and keeps autoimmune reactions under control. Under disease conditions like cancers, dysregulation of miRNA leads to increased PDL-1 expression and helps cancer cells to evade immune response by T cells (Danbaran et al., 2020, Kao et al., 2017, Grenda et al., 2017).
Literature References
PubMed ID Title Journal Year
29186904 The Roles of microRNAs in Regulating the Expression of PD-1/PD-L1 Immune Checkpoint

Wang, Q, Lin, W, Tang, X, Li, S, Guo, L, Lin, Y, Kwok, HF

Int J Mol Sci 2017
32544493 Immunomodulatory role for MicroRNAs: Regulation of PD-1/PD-L1 and CTLA-4 immune checkpoints expression

Skafi, N, Fayyad-Kazan, M, Badran, B

Gene 2020
32416456 How microRNAs affect the PD-L1 and its synthetic pathway in cancer

Danbaran, GR, Aslani, S, Sharafkandi, N, Hemmatzadeh, M, Hosseinzadeh, R, Azizi, G, Jadidi-Niaragh, F, Babaie, F, Mohammadi, H

Int Immunopharmacol 2020
28629895 Tumor Suppressor microRNAs Contribute to the Regulation of PD-L1 Expression in Malignant Pleural Mesothelioma

Kao, SC, Cheng, YY, Williams, M, Kirschner, MB, Madore, J, Lum, T, Sarun, KH, Linton, A, McCaughan, B, Klebe, S, van Zandwijk, N, Scolyer, RA, Boyer, MJ, Cooper, WA, Reid, G

J Thorac Oncol 2017
28675453 New Dancing Couple: PD-L1 and MicroRNA

Grenda, A, Krawczyk, P

Scand J Immunol 2017
Participants
Input
Output
Participates
as an event of
This event is regulated
Negatively by
Regulator
CD274 mRNA:miR140 RISC [cytosol] (Homo sapiens)
Active Unit
miR-140 RISC [cytosol]
Regulator
CD274 mRNA:miR424 RISC [cytosol] (Homo sapiens)
Active Unit
miR-424 RISC [cytosol]
Regulator
CD274 mRNA:miR-142-5p RISC [cytosol] (Homo sapiens)
Active Unit
miR-142-5p RISC [cytosol]
Regulator
CD274 mRNA:miR-148a-3p RISC [cytosol] (Homo sapiens)
Active Unit
miR-148a-3p RISC [cytosol]
Regulator
CD274 mRNA:miR-340 RISC [cytosol] (Homo sapiens)
Active Unit
miR-340 RISC [cytosol]
Regulator
CD274:miR-200B/C RISC [cytosol] (Homo sapiens)
Active Unit
miR-200B/C RISC [cytosol]
Regulator
CD274 mRNA:miR-93 RISC [cytosol] (Homo sapiens)
Active Unit
miR-93 RISC [cytosol]
Regulator
CD274 mRNA:miR-let7-a1 RISC [cytosol] (Homo sapiens)
Active Unit
miR-Let7-a1 RISC [cytosol]
Regulator
CD274 mRNA:miR-152 RISC [cytosol] (Homo sapiens)
Active Unit
miR-152 RISC [cytosol]
Regulator
CD274 mRNA:miR-429 RISC [cytosol] (Homo sapiens)
Active Unit
miR-429 RISC [cytosol]
Regulator
CD274 mRNA:miR-34 RISC [cytosol] (Homo sapiens)
Active Unit
miR-34 RISC [cytosol]
Regulator
CD274 mRNA:miR-138-5p RISC [cytosol] (Homo sapiens)
Active Unit
miR-138-5p RISC [cytosol]
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-10-16)
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