CD274 mRNA binds miR-429 RISC

Stable Identifier
R-HSA-9924968
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CD274 mRNA binds miR-429 RISC
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Being a member of miR-200 family, MicroRNA-429 (miR-429) role is extensively studied in tumorigenesis regulating cell growth and invasion. It acts as a tumor suppressor by suppressing cell proliferation and migration (Wang et al., 2019, Sun et al., 2014). It also get expressed during hypoxia by HIF1 and regulates multiple downstream targets (Bartoszewska et al., 2023). miR-429 acts as a negative regulator of CD274 (PD-L1) expression by binding to its 3' UTR, suppressing its translation, and thus reducing its expression (Lv et al., 2020; Yu et al., 2023).
Literature References
PubMed ID Title Journal Year
37775648 miR-429 inhibits the formation of an immunosuppressive microenvironment to counteract hepatocellular carcinoma immune escape by targeting PD-L1

Yu, X, Fan, X, Zhang, X, Wei, P, Zhou, H, Liu, D, Chen, B

Funct Integr Genomics 2023
32775300 PD-L1 Under Regulation of miR-429 Influences the Sensitivity of Gastric Cancer Cells to TRAIL by Binding of EGFR

Lv, J, Guo, T, Qu, X, Che, X, Li, C, Wang, S, Gong, J, Wu, P, Liu, Y, Liu, Y, Xu, L

Front Oncol 2020
Participants
Input
Output
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as an event of
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-10-16)
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