CD274 mRNA binds miR-138-5p RISC

Stable Identifier
R-HSA-9925087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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CD274 mRNA binds miR-138-5p RISC
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MicroRNA 138 5p (miR-429-5p) plays a role in immune checkpoint regulation by regulating PDL1 expression. It is a tumor suppressor and its expression is downregulated in multiple cancers (Zhao et al., 2016, Yang et al., 2016). miR- 429-5p suppresses CD274 (PD-L1) expression by directly binding to 3’ UTR of the PDL1 mRNA and inhibiting its translation, reported through luciferase reporter assays (Rostami et al., 2024, Zhao et al., 2016)
Literature References
PubMed ID Title Journal Year
27248318 The tumor suppressor miR-138-5p targets PD-L1 in colorectal cancer

Zhao, L, Yu, H, Yi, S, Peng, X, Su, P, Xiao, Z, Liu, R, Tang, A, Li, X, Liu, F, Shen, S

Oncotarget 2016
38866824 PDL1 targeting by miR-138-5p amplifies anti-tumor immunity and Jurkat cells survival in non-small cell lung cancer

Rostami, F, Tavakol Hamedani, Z, Sadoughi, A, Mehrabadi, M, Kouhkan, F

Sci Rep 2024
Participants
Input
Output
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as an event of
Authored
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Tiwari, K  (2024-11-05)
Reviewed
Hung, MC  (2025-08-26)
Yamaguchi, H  (2025-08-26)
Created
Tiwari, K  (2024-10-16)
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