Reactome | p-S65-PRKN [cytosol]

p-S65-PRKN [cytosol]

Stable Identifier

R-HSA-9834954

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-S65-PARK2, Parkin, E3 ubiquitin-protein ligase parkin

Locations in the PathwayBrowser for interactor IntAct:EBI-4399559 UBIQ

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External Reference Information

External Reference

UniProt:O60260 PRKN

Gene Names

PRKN, PARK2

Chain

chain:1-465

Reference Genes

BioGPS Gene:5071 PRKN

COSMIC - genes:PRKN PRKN

CTD Gene:5071 PRKN

dbSNP Gene:5071 PRKN

ENSEMBL:ENSG00000185345 PRKN

HGNC:8607 PRKN

KEGG:hsa:5071 PRKN

Monarch:5071 PRKN

NCBI Gene:5071 PRKN

OMIM:602544 PRKN

UCSC:O60260 PRKN

Reference Transcript

Participates

as an output of

PRKN ubiquitinates MOM substrates (Homo sapiens)

as a component of

p-S65-PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Homo sapiens)

Other forms of this molecule

PRKN [cytosol]

p-S9-PRKN [cytosol]

polyUb-PARK2 [cytosol]

Inferred To

phospho-prkn [cytosol] (Danio rerio)

phospho-pdr-1 [cytosol] (Caenorhabditis elegans)

phospho-PRKN [cytosol] (Bos taurus)

phospho-PRKN [cytosol] (Canis familiaris)

phospho-p-S65-PRKN [cytosol] (Drosophila melanogaster)

phospho-p-S65-PRKN [cytosol] (Mus musculus)

phospho-p-S65-PRKN [cytosol] (Rattus norvegicus)

phospho-p-S65-PRKN [cytosol] (Saccharomyces cerevisiae)

Modified Residues

Name

O-phospho-L-serine at 65

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_004553.2, NP_054642.2, NP_054643.2

ENSEMBL

ENSP00000355862, ENSP00000355863, ENST00000366898, ENSP00000355865, ENST00000479615, ENSG00000185345, ENSP00000434414, ENST00000366896, ENST00000366897

OpenTargets

ENSG00000185345

HPA

ENSG00000185345-PRKN

GeneCards

PRKN

PRO

O60260

Pharos - Targets

O60260

GlyGen

O60260

Orphanet

PRKN

HMDB Protein

HMDBP07955

PDB

8WZN, 4I1F, 8JWV, 5C9V, 4I1H, 8IKM, 1IYF, 8IKT, 5TR5, 6HUE, 8IK6, 8IKV, 5N2W, 5N38, 4BM9, 5C23, 8WZO, 5C1Z, 2JMO, 6N13, 6GLC

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BXM7 PINK1	5	p-S228,S402-PINK1 [mitochondrial outer membrane] (R-HSA-9834051) PINK1 [mitochondrial outer membrane] (R-HSA-5205653) PINK1 [mitochondrial intermembrane space] (R-HSA-5205671) PINK1 [cytosol] (R-HSA-5205637) PINK1(111-581) [mitochondrial intermembrane space] (R-HSA-5205628)	0.748	7
UniProt:Q15645 PCH2			0.712	4
UniProt:P49792 RANBP2	6	RANBP2 [cytosol] (R-HSA-157703) RANBP2(1-867)-ALK(1058-1620) fusion [cytosol] (R-HSA-9702002) RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9718443) RANBP2 [nuclear envelope] (R-HSA-2993756) monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope] (R-HSA-4551599) polySUMO2-K2652,K2725-RANBP2 [nuclear envelope] (R-HSA-4551720)	0.639	11
IntAct:EBI-4399559 UBIQ			0.623	2
UniProt:Q9Y3I1 FBXO7	1	FBXO7 [cytosol] (R-HSA-8862627)	0.623	10
UniProt:O60260 PRKN	4	PRKN [cytosol] (R-HSA-201579) p-S65-PRKN [cytosol] (R-HSA-9834954) p-S9-PRKN [cytosol] (R-HSA-9793481) polyUb-PARK2 [cytosol] (R-HSA-5689094)	0.618	5
UniProt:P68510 Ywhah	1	14-3-3 eta [cytosol] (R-MMU-1445091)	0.611	6
UniProt:Q9UBN7 HDAC6	4	HDAC6 [lysosomal lumen] (R-HSA-9660002) HDAC6 [cytosol] (R-HSA-5324660) HDAC6 [late endosome lumen] (R-HSA-9659980) HDAC6 [nucleoplasm] (R-HSA-351589)	0.602	6
UniProt:Q6NUN9 ZNF746	1	ZNF746 [nucleoplasm] (R-HSA-2586599)	0.591	6
UniProt:Q8IZ52-2 CHPF			0.581	5
UniProt:O95140 MFN2	5	p-S65-Ub:MFN2 [mitochondrial outer membrane] (R-HSA-9834980) K63polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-9834043) K48polyUb-MFN2 [mitochondrial outer membrane] (R-HSA-5205668) Ub-MFN2 [mitochondrial outer membrane] (R-HSA-9835010) MFN2 [mitochondrial outer membrane] (R-HSA-992714)	0.576	4
UniProt:Q12959 DLG1	4	DLG1 [plasma membrane] (R-HSA-375977) DLG1 [transport vesicle membrane] (R-HSA-9610631) DLG1 [endoplasmic reticulum membrane] (R-HSA-9610593) DLG1 [cytosol] (R-HSA-416332)	0.571	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477)	0.564	2
UniProt:P41220 RGS2	1	RGS2 [plasma membrane] (R-HSA-939787)	0.553	2
UniProt:Q9BXM7-1 PINK1			0.544	2
UniProt:P55072 VCP	8	VCP [cytosol] (R-HSA-1181251) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [extracellular region] (R-HSA-6806191) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [secretory granule lumen] (R-HSA-6801039) VCP [nucleoplasm] (R-HSA-5643745) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) Me3K315-VCP [cytosol] (R-HSA-8932209)	0.527	2
UniProt:O14818-1 PSMA7			0.524	5
UniProt:Q8IXI2 RHOT1	2	PolyUb-RHOT1 [mitochondrial outer membrane] (R-HSA-6783139) RHOT1 [mitochondrial outer membrane] (R-HSA-3006728)	0.524	3
UniProt:Q9Z2Q6 SEPT5			0.508	2
UniProt:Q99IB8-PRO_0000045592			0.508	3
UniProt:Q16342 PDCD2			0.508	5
UniProt:Q99963-3 SH3GL3			0.462	2
UniProt:O35179 Sh3gl2	5	Sh3gl2 [Golgi membrane] (R-RNO-351189) Sh3gl2 [clathrin-coated endocytic vesicle membrane] (R-RNO-2130629) Endophilin [plasma membrane] (R-RNO-182026) Sh3gl2 [plasma membrane] (R-RNO-177495) Sh3gl2 [cytosol] (R-RNO-182958)	0.462	2
UniProt:O35964	1	Sh3gl1 [cytosol] (R-RNO-8867732)	0.462	2

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