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MFN2
Stable Identifier
R-HSA-992714
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Mitofusin-2, MFN2_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Factors involved in megakaryocyte development and platelet production (Homo sapiens)
Mitofusins trans-interact linking mitochondria prior to fusion (Homo sapiens)
Mitofusin complex [mitochondrial outer membrane] (Homo sapiens)
Mitofusins [mitochondrial outer membrane] (Homo sapiens)
MFN2 [mitochondrial outer membrane] (Homo sapiens)
Mitofusins [mitochondrial outer membrane] (Homo sapiens)
MFN2 [mitochondrial outer membrane] (Homo sapiens)
Mitophagy (Homo sapiens)
Pink/Parkin Mediated Mitophagy (Homo sapiens)
Parkin promotes the ubiquitination of mitochondrial substrates (Homo sapiens)
MFN2 [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O95140 MFN2
Gene Names
MFN2, CPRP1, KIAA0214
Chain
chain:1-757
Reference Genes
BioGPS Gene:9927 MFN2
COSMIC (genes):MFN2 MFN2
CTD Gene:9927 MFN2
dbSNP Gene:9927 MFN2
ENSEMBL:ENSG00000116688 MFN2
HGNC:16877 MFN2
KEGG Gene (Homo sapiens):hsa:9927 MFN2
Monarch:9927 MFN2
NCBI Gene:9927 MFN2
OMIM:608507 MFN2
UCSC:O95140 MFN2
Reference Transcript
RefSeq:NM_014874.3 MFN2
RefSeq:XM_005263548.3 MFN2
RefSeq:XM_005263547.3 MFN2
RefSeq:NM_001127660.1 MFN2
RefSeq:XM_005263545.3 MFN2
RefSeq:XM_005263543.3 MFN2
Other Identifiers
0003940167
11739020_a_at
11741010_a_at
11748427_a_at
16659171
201155_s_at
216205_s_at
30554
34369_at
7897824
9927
A_14_P132643
A_23_P126135
A_33_P3320277
AAD02058
AAH17061
AAK18728
AF036536
AK289828
AL096840
AL137666
AY028429
BAA34389
BAF82517
BC017061
CAB70866
CAI19087
CAI19088
CCDS30587
CH471130
D86987
EAW71726
ENSG00000116688
ENSP00000235329
ENSP00000416338
ENST00000235329
ENST00000444836
EntrezGene:9927
g7662003_3p_a_at
GE57383
GO:0000166
GO:0001825
GO:0003674
GO:0003924
GO:0005515
GO:0005525
GO:0005575
GO:0005622
GO:0005623
GO:0005737
GO:0005739
GO:0005741
GO:0005829
GO:0005856
GO:0006605
GO:0006626
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0006986
GO:0007005
GO:0007006
GO:0007165
GO:0007596
GO:0008053
GO:0008150
GO:0008219
GO:0008283
GO:0009056
GO:0009790
GO:0015630
GO:0016020
GO:0016021
GO:0016236
GO:0016787
GO:0019899
GO:0022607
GO:0031306
GO:0031625
GO:0034497
GO:0043167
GO:0043226
GO:0046580
GO:0048593
GO:0048646
GO:0048662
GO:0048856
GO:0051646
GO:0061024
GO:0061734
HGNC:16877
HPA030554
Hs.3363.2.S1_3p_a_at
Hs.376681
ILMN_1651385
IPR006884
IPR022812
IPR027089
IPR027417
IPR030381
LRG_255
LRG_255t1
MFN2
MFN2-201
MFN2-203
MIM:601152
MIM:608507
MIM:609260
MIM:617087
NM_001127660
NM_014874
NP_001121132
NP_055689
PF00350
PF04799
PH_hs_0024267
TC01000152.hg
uc001atn.5
uc009vni.4
UPI0000039854
XM_005263543
XM_005263545
XM_005263547
XM_005263548
XP_005263600
XP_005263602
XP_005263604
XP_005263605
Participant Of
input
Parkin promotes the ubiquitination of mitochondrial substrates
hasMember
Mitofusins [mitochondrial outer membrane]
Other forms of this molecule
K48polyUb-MFN2 [mitochondrial outer membrane]
Inferred To
Homologues of MFN2 [mitochondrial outer membrane] (Drosophila melanogaster)
Homologues of MFN2 [mitochondrial outer membrane] (Rattus norvegicus)
Homologues of MFN2 [mitochondrial outer membrane] (Taeniopygia guttata)
Homologues of MFN2 [mitochondrial outer membrane] (Xenopus tropicalis)
MFN2 [mitochondrial outer membrane] (Bos taurus)
MFN2 [mitochondrial outer membrane] (Caenorhabditis elegans)
MFN2 [mitochondrial outer membrane] (Canis familiaris)
MFN2 [mitochondrial outer membrane] (Danio rerio)
MFN2 [mitochondrial outer membrane] (Drosophila melanogaster)
MFN2 [mitochondrial outer membrane] (Gallus gallus)
MFN2 [mitochondrial outer membrane] (Mus musculus)
MFN2 [mitochondrial outer membrane] (Rattus norvegicus)
MFN2 [mitochondrial outer membrane] (Sus scrofa)
MFN2 [mitochondrial outer membrane] (Taeniopygia guttata)
MFN2 [mitochondrial outer membrane] (Xenopus tropicalis)
Cross References
RefSeq
XP_005263600.1
,
NP_001121132.1
,
XP_005263605.1
,
NP_055689.1
,
XP_005263602.1
,
XP_005263604.1
GeneCards
O95140
PRO
O95140
Orphanet
16394
HMDB Protein
HMDBP08482
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60260 PRKN
2
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
PARK2 [cytosol]
(R-HSA-201579)
0.576
4
UniProt:Q16611 BAK1
2
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.463
3
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