Reactome | MFN2 [mitochondrial outer membrane]

MFN2 [mitochondrial outer membrane]

Stable Identifier

R-HSA-992714

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial outer membrane

Synonyms

Mitofusin-2, MFN2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O95140 MFN2

Gene Names

MFN2, CPRP1, KIAA0214

Chain

chain:1-757

Reference Genes

BioGPS Gene:9927 MFN2

COSMIC (genes):MFN2 MFN2

CTD Gene:9927 MFN2

dbSNP Gene:9927 MFN2

ENSEMBL:ENSG00000116688 MFN2

HGNC:16877 MFN2

KEGG:hsa:9927 MFN2

Monarch:9927 MFN2

NCBI Gene:9927 MFN2

OMIM:608507 MFN2

UCSC:O95140 MFN2

Reference Transcript

Other Identifiers

11739020_a_at

11741010_a_at

11748427_a_at

16659171

201155_PM_s_at

201155_s_at

216205_PM_s_at

216205_s_at

2320620

2320622

2320623

2320624

2320625

2320626

2320628

2320629

2320630

2320631

2320632

2320633

2320635

2320636

2320637

2320638

2320639

2320641

2320642

2320643

2320644

2320645

2320646

2320647

2320648

2320649

2320650

2320651

2320652

2320653

2320654

2320655

2320656

34369_at

68083_at

7897824

9927

A_14_P132643

A_23_P126135

A_33_P3320277

GE57383

GO:0001825

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005739

GO:0005741

GO:0005829

GO:0005856

GO:0006091

GO:0006626

GO:0006914

GO:0006915

GO:0006986

GO:0007005

GO:0007006

GO:0008053

GO:0009060

GO:0012501

GO:0015630

GO:0016020

GO:0016787

GO:0031625

GO:0034497

GO:0043226

GO:0046580

GO:0048593

GO:0048662

GO:0051646

GO:0061024

GO:0061734

GO:0120162

GO:1904707

GO:1905461

HMNXSV003052093

Hs.3363.2.S1_3p_a_at

ILMN_1651385

PH_hs_0024267

TC01000152.hg

g7662003_3p_a_at

Participates

as a member of

Other forms of this molecule

p-S65-Ub:MFN2 [mitochondrial outer membrane]

K63polyUb-MFN2 [mitochondrial outer membrane]

K48polyUb-MFN2 [mitochondrial outer membrane]

Ub-MFN2 [mitochondrial outer membrane]

Inferred To

Homologues of MFN2 [mitochondrial outer membrane] (Drosophila melanogaster)

MFN2 [mitochondrial outer membrane] (Bos taurus)

MFN2 [mitochondrial outer membrane] (Caenorhabditis elegans)

MFN2 [mitochondrial outer membrane] (Canis familiaris)

MFN2 [mitochondrial outer membrane] (Drosophila melanogaster)

MFN2 [mitochondrial outer membrane] (Gallus gallus)

MFN2 [mitochondrial outer membrane] (Mus musculus)

MFN2 [mitochondrial outer membrane] (Plasmodium falciparum)

MFN2 [mitochondrial outer membrane] (Rattus norvegicus)

MFN2 [mitochondrial outer membrane] (Saccharomyces cerevisiae)

MFN2 [mitochondrial outer membrane] (Schizosaccharomyces pombe)

MFN2 [mitochondrial outer membrane] (Sus scrofa)

mfn2 [mitochondrial outer membrane] (Xenopus tropicalis)

Cross References

RefSeq

XP_005263605.1, XP_005263604.1, NP_055689.1, XP_005263602.1, XP_005263600.1, NP_001121132.1

Guide to Pharmacology - Targets

3131

ENSEMBL

ENST00000675053, ENST00000444836, ENSP00000235329, ENSP00000502623, ENSP00000502404, ENSG00000116688, ENSP00000501776, ENST00000675231, ENST00000676293, ENST00000235329, ENSP00000501716, ENSP00000416338, ENSP00000502362, ENST00000674910, ENST00000674817, ENST00000674548, ENSP00000502151, ENSP00000502185, ENST00000675919, ENSP00000501646, ENST00000675113

OpenTargets

ENSG00000116688

HPA

ENSG00000116688-MFN2

GeneCards

MFN2

PRO

O95140

Pharos - Targets

O95140

Orphanet

MFN2

HMDB Protein

HMDBP08482

PDB

6JFL, 6JFM, 6JFK

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O60260 PARK2	4	PRKN [cytosol] (R-HSA-201579) p-S65-PRKN [cytosol] (R-HSA-9834954) p-S9-PRKN [cytosol] (R-HSA-9793481) polyUb-PARK2 [cytosol] (R-HSA-5689094)	0.576	4
UniProt:Q16611 BAK1	2	BAK1 activated [mitochondrial outer membrane] (R-HSA-50690) BAK1 [mitochondrial outer membrane] (R-HSA-139896)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.463	3

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