Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PRKN [cytosol]
Stable Identifier
R-HSA-201579
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
PARK2, Parkin, E3 ubiquitin-protein ligase parkin
Icon
Locations in the PathwayBrowser
Expand all
Autophagy (Homo sapiens)
Macroautophagy (Homo sapiens)
Selective autophagy (Homo sapiens)
Aggrephagy (Homo sapiens)
Misfolded proteins bind PRKN:UBE2N:UBE2V1:Ub (Homo sapiens)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Homo sapiens)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Parkin transfers Ub to misfolded proteins (Homo sapiens)
Misfolded proteins:PRKN:UBE2N:UBE2V1:Ub [cytosol] (Homo sapiens)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Homo sapiens)
UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
PolyUb:misfolded proteins dissociate from PRKN:UBE2N:UBE2V1 (Homo sapiens)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Homo sapiens)
UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Ub:misfolded proteins polymerize to PolyUb:misfolded proteins (Homo sapiens)
PolyUb:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Homo sapiens)
UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Ub:Misfolded proteins:PRKN:UBE2N:UBE2V1 [cytosol] (Homo sapiens)
UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Mitophagy (Homo sapiens)
PINK1-PRKN Mediated Mitophagy (Homo sapiens)
PINK1 phosphorylates PRKN at S65 (Homo sapiens)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
PRKN binds p-S-Ub:MOM proteins (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
PARK2 K63-Ubiquitinates SNCAIP (Homo sapiens)
PARK2:SNCAIP [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
PARK2 binds SNCAIP (Homo sapiens)
PARK2:SNCAIP [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Josephin domain DUBs (Homo sapiens)
ATXN3 deubiquitinates polyUb-PARK2 (Homo sapiens)
ATXN3:PARK2 [cytosol] (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
PARK2 autoubiquitinates (Homo sapiens)
PRKN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60260 PARK2
Gene Names
PARK2, PRKN
Chain
chain:1-465
Reference Genes
COSMIC (genes):PRKN PRKN
dbSNP Gene:5071 PRKN
ENSEMBL:ENSG00000185345 PARK2
Participates
as a component of
ATXN3:PARK2 [cytosol] (Homo sapiens)
PARK2:SNCAIP [cytosol] (Homo sapiens)
PRKN:Ub-MOM proteins [mitochondrial outer membrane] (Homo sapiens)
Ub:UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
UBE2N:UBE2V1:PRKN [cytosol] (Homo sapiens)
as an input of
PARK2 autoubiquitinates (Homo sapiens)
PARK2 binds SNCAIP (Homo sapiens)
PRKN binds p-S-Ub:MOM proteins (Homo sapiens)
Parkin binds Ub:UBE2N:UBE2V1 (Homo sapiens)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Other forms of this molecule
polyUb-PARK2 [cytosol]
p-S9-PRKN [cytosol]
p-S65-PRKN [cytosol]
Inferred To
PRKN [cytosol]
(Bos taurus)
PRKN [cytosol]
(Canis familiaris)
PRKN [cytosol]
(Dictyostelium discoideum)
PRKN [cytosol]
(Drosophila melanogaster)
PRKN [cytosol]
(Gallus gallus)
PRKN [cytosol]
(Mus musculus)
PRKN [cytosol]
(Plasmodium falciparum)
PRKN [cytosol]
(Rattus norvegicus)
PRKN [cytosol]
(Saccharomyces cerevisiae)
PRKN [cytosol]
(Schizosaccharomyces pombe)
Homologues of PRKN [cytosol]
(Dictyostelium discoideum)
Ghost homologue of PRKN [cytosol]
(Caenorhabditis elegans)
Ghost homologue of PRKN [cytosol]
(Sus scrofa)
prkn [cytosol]
(Danio rerio)
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BXM7 PINK1
5
PINK1(111-581) [mitochondrial intermembrane space]
(R-HSA-5205628)
PINK1 [cytosol]
(R-HSA-5205637)
PINK1 [mitochondrial intermembrane space]
(R-HSA-5205671)
PINK1 [mitochondrial outer membrane]
(R-HSA-5205653)
p-S228,S402-PINK1 [mitochondrial outer membrane]
(R-HSA-9834051)
0.748
7
UniProt:Q15645 PCH2
0.712
4
UniProt:P49792 RANBP2
6
RANBP2 [cytosol]
(R-HSA-157703)
RANBP2(1-867)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9702002)
RANBP2(1-867)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9718443)
RANBP2 [nuclear envelope]
(R-HSA-2993756)
monoSUMO1-K2592,K2650,K2723-RANBP2 [nuclear envelope]
(R-HSA-4551599)
polySUMO2-K2652,K2725-RANBP2 [nuclear envelope]
(R-HSA-4551720)
0.639
11
UniProt:Q9Y3I1 FBXO7
1
FBXO7 [cytosol]
(R-HSA-8862627)
0.623
10
IntAct:EBI-4399559 UBIQ
0.623
2
UniProt:O60260 PARK2
4
polyUb-PARK2 [cytosol]
(R-HSA-5689094)
p-S9-PRKN [cytosol]
(R-HSA-9793481)
p-S65-PRKN [cytosol]
(R-HSA-9834954)
PRKN [cytosol]
(R-HSA-201579)
0.618
5
UniProt:P68510 Ywhah
1
14-3-3 eta [cytosol]
(R-MMU-1445091)
0.611
6
UniProt:Q9UBN7 HDAC6
4
HDAC6 [lysosomal lumen]
(R-HSA-9660002)
HDAC6 [cytosol]
(R-HSA-5324660)
HDAC6 [late endosome lumen]
(R-HSA-9659980)
HDAC6 [nucleoplasm]
(R-HSA-351589)
0.602
6
UniProt:Q6NUN9 ZNF746
1
ZNF746 [nucleoplasm]
(R-HSA-2586599)
0.591
6
UniProt:Q8IZ52-2 CHPF
0.581
5
UniProt:O95140 MFN2
5
p-S65-Ub:MFN2 [mitochondrial outer membrane]
(R-HSA-9834980)
K63polyUb-MFN2 [mitochondrial outer membrane]
(R-HSA-9834043)
K48polyUb-MFN2 [mitochondrial outer membrane]
(R-HSA-5205668)
Ub-MFN2 [mitochondrial outer membrane]
(R-HSA-9835010)
MFN2 [mitochondrial outer membrane]
(R-HSA-992714)
0.576
4
UniProt:P08238 HSP90AB1
6
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
0.564
2
UniProt:P41220 RGS2
1
RGS2 [plasma membrane]
(R-HSA-939787)
0.553
2
UniProt:Q9BXM7-1 PINK1
0.544
2
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.527
2
UniProt:Q8IXI2 RHOT1
2
PolyUb-RHOT1 [mitochondrial outer membrane]
(R-HSA-6783139)
RHOT1 [mitochondrial outer membrane]
(R-HSA-3006728)
0.524
3
UniProt:O14818-1 PSMA7
0.524
5
UniProt:Q16342 PDCD2
0.508
5
UniProt:Q99IB8-PRO_0000045592
0.508
3
UniProt:Q9Z2Q6 SEPT5
0.508
2
UniProt:O35964
1
Sh3gl1 [cytosol]
(R-RNO-8867732)
0.462
2
UniProt:O35179 Sh3gl2
5
Sh3gl2 [Golgi membrane]
(R-RNO-351189)
Sh3gl2 [clathrin-coated endocytic vesicle membrane]
(R-RNO-2130629)
Sh3gl2 [cytosol]
(R-RNO-182958)
Endophilin [plasma membrane]
(R-RNO-182026)
Sh3gl2 [plasma membrane]
(R-RNO-177495)
0.462
2
UniProt:Q99963-3 SH3GL3
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text