Reactome | GAN [cytosol]

GAN [cytosol]

Stable Identifier

R-HSA-976014

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Gigaxonin, GAN_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Neddylation (Homo sapiens)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Homo sapiens)
        
        CRL E3 ubiquitin ligases [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Homo sapiens)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Homo sapiens)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Homo sapiens)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Homo sapiens)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Homo sapiens)
        
        RBX1:CUL3:BTB [cytosol] (Homo sapiens)
        
        BTB proteins [cytosol] (Homo sapiens)
        
        GAN [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9H2C0 GAN

Gene Names

GAN, GAN1, KLHL16

Chain

chain:1-597

Reference Genes

BioGPS Gene:8139 GAN

COSMIC (genes):GAN GAN

CTD Gene:8139 GAN

dbSNP Gene:8139 GAN

ENSEMBL:ENSG00000261609 GAN

HGNC:4137 GAN

KEGG:hsa:8139 GAN

Monarch:8139 GAN

NCBI Gene:8139 GAN

OMIM:605379 GAN

UCSC:Q9H2C0 GAN

Reference Transcript

RefSeq:NM_022041.3 GAN

Other Identifiers

11734181_at

16821280

16821294

220124_PM_at

220124_at

228567_PM_at

228567_at

2593628

3670726

3670727

3670728

3670735

3670736

3670737

3670738

3670739

3670740

3670741

3670743

3670744

3670746

3670747

3670749

3670750

3670751

3670752

3670753

3670754

3670755

3670756

3670757

3670758

3670760

3670761

3670762

45627_at

55916_at

75539_at

7997414

8139

A_14_P133164

A_14_P134136

A_23_P88873

A_32_P24651

GE80020

GE900888

GO:0003674

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0007010

GO:0016567

GO:0031463

GO:0043226

HMNXSV003008429

HMNXSV003020979

HMNXSV003033411

Hs.46824.0.A1_3p_at

ILMN_1708103

ILMN_1851492

PH_hs_0006172

PH_hs_0018123

TC16000638.hg

TC16000639.hg

TC16001658.hg

TC16001659.hg

g11545730_3p_at

p25043

p6537

p6538

Participates

as a member of

BTB proteins [cytosol] (Homo sapiens)

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

GAN [cytosol] (Bos taurus)

GAN [cytosol] (Canis familiaris)

GAN [cytosol] (Dictyostelium discoideum)

GAN [cytosol] (Gallus gallus)

GAN [cytosol] (Plasmodium falciparum)

GAN [cytosol] (Sus scrofa)

gan [cytosol] (Xenopus tropicalis)

Dm.CG15097 [cytosol] (Drosophila melanogaster)

Gan [cytosol] (Mus musculus)

Gan [cytosol] (Rattus norvegicus)

Cross References

ENSEMBL

ENST00000648994, ENSP00000497351, ENSG00000261609

OpenTargets

ENSG00000261609

GeneCards

GAN

HPA

ENSG00000261609-GAN

PRO

Q9H2C0

Pharos - Targets

Q9H2C0

GlyGen

Q9H2C0

Orphanet

GAN

PDB

3HVE, 2PPI

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.641	3
UniProt:P46821 MAP1B	1	MAP1B(2-2206) [cytosol] (R-HSA-9836954)	0.557	3
UniProt:Q5U300	2	UBA1 [nucleoplasm] (R-RNO-8852116) UBA1 [cytosol] (R-RNO-947698)	0.544	2
UniProt:P22314 UBA1	2	UBA1 [cytosol] (R-HSA-947698) UBA1 [nucleoplasm] (R-HSA-8852116)	0.527	3
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.527	2
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	3
UniProt:Q96JH7 VCPIP1	2	p-S131-VCPIP1 [endoplasmic reticulum lumen] (R-HSA-8940104) VCPIP1 [endoplasmic reticulum lumen] (R-HSA-8940103)	0.527	3
UniProt:Q9Y3M2 CBY1	3	pS20-CBY1 [nucleoplasm] (R-HSA-3769356) CBY1 [nucleoplasm] (R-HSA-3769210) pS20-CBY1 [cytosol] (R-HSA-3769354)	0.508	2
UniProt:Q99426 TBCB	1	TBCB [cytosol] (R-HSA-379546)	0.508	3