Reactome | GAN [cytosol]

GAN [cytosol]

Stable Identifier

R-SSC-976014

Type

Protein [EntityWithAccessionedSequence]

Species

Sus scrofa

Compartment

cytosol

Synonyms

GAN, A0A5G2QGY3

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Sus scrofa)

- Post-translational protein modification (Sus scrofa)
  - Neddylation (Sus scrofa)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Sus scrofa)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        RBX1:CUL3:BTB [cytosol] (Sus scrofa)
        
        BTB proteins [cytosol] (Sus scrofa)
        
        GAN [cytosol] (Sus scrofa)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Sus scrofa)
        
        BTB proteins [cytosol] (Sus scrofa)
        
        GAN [cytosol] (Sus scrofa)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        RBX1:CUL3:BTB [cytosol] (Sus scrofa)
        
        BTB proteins [cytosol] (Sus scrofa)
        
        GAN [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        RBX1:CUL3:BTB [cytosol] (Sus scrofa)
        
        BTB proteins [cytosol] (Sus scrofa)
        
        GAN [cytosol] (Sus scrofa)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Sus scrofa)
        
        CRL E3 ubiquitin ligases [cytosol] (Sus scrofa)
        
        RBX1:CUL3:BTB [cytosol] (Sus scrofa)
        
        BTB proteins [cytosol] (Sus scrofa)
        
        GAN [cytosol] (Sus scrofa)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Sus scrofa)
        
        RBX1:CUL3:BTB [cytosol] (Sus scrofa)
        
        BTB proteins [cytosol] (Sus scrofa)
        
        GAN [cytosol] (Sus scrofa)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Sus scrofa)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
        
        RBX1:CUL3:BTB [cytosol] (Sus scrofa)
        
        BTB proteins [cytosol] (Sus scrofa)
        
        GAN [cytosol] (Sus scrofa)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Sus scrofa)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Sus scrofa)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Sus scrofa)
        
        BTB proteins [cytosol] (Sus scrofa)
        
        GAN [cytosol] (Sus scrofa)

External Reference Information

External Reference

UniProt:A0A5G2QGY3

Gene Names

GAN

Reference Genes

ENSEMBL:ENSSSCG00000002690.5

Other Identifiers

100518489

GO:0005515

GO:0005737

GO:0007010

GO:0016567

GO:0031463

GO:0036211

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Sus scrofa)

as a member of

BTB proteins [cytosol] (Sus scrofa)

Inferred From

GAN [cytosol] (Homo sapiens)

Cross References

OpenTargets

ENSG00000261609

Ensembl

ENSSSCT00000089898, ENSSSCG00000002690, ENSSSCP00000061272

VGNC

88343

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