Reactome | Gan [cytosol]

Gan [cytosol]

Stable Identifier

R-MMU-976014

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

GAN, Q8CA72

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2M transfers NEDD8 to CRL3 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL3 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        NEDD8-CUL3:RBX1:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2M binds CRL3 E3 ubiquitin ligase complex (Mus musculus)
      - CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2M:CRL3 E3 ubiquitin ligase :DCUN1D1,2,4,5 [cytosol] (Mus musculus)
        
        CRL3 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        RBX1:CUL3:BTB [cytosol] (Mus musculus)
        
        BTB proteins [cytosol] (Mus musculus)
        
        Gan [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q8CA72

Gene Names

Gan

Reference Genes

BioGPS Gene:209239 Gan

ENSEMBL:ENSMUSG00000052557

KEGG:mmu:209239 Gan

Monarch:209239 Gan

NCBI Gene:209239 Gan

UCSC:Q8CA72 Gan

Other Identifiers

10575763

107410_at

1434845_at

1439615_at

1458444_at

167042_i_at

17505953

17548650

209239

4317916

4462011

4640702

4774527

4800984

4819839

4895856

4935054

4967301

5051557

5070530

5074406

5206549

5274185

5438324

5454642

5476371

5481447

5493345

5587470

A_30_P01017425

A_30_P01017507

A_30_P01017746

A_30_P01018462

A_30_P01019255

A_30_P01021751

A_30_P01021814

A_30_P01022396

A_30_P01025839

A_30_P01026233

A_30_P01026866

A_30_P01028218

A_30_P01028695

A_30_P01032012

A_51_P125986

A_55_P2920841

GE1389282

GE1493554

GO:0005515

GO:0005737

GO:0005856

GO:0007010

GO:0016567

GO:0030163

GO:0031463

GO:0043161

GO:0060090

GO:1990756

ILMN_1218451

ILMN_1228488

ILMN_3091801

mMC015178

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Mus musculus)

as a member of

BTB proteins [cytosol] (Mus musculus)

Inferred From

GAN [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_001074620.1

ENSEMBL

ENSMUSP00000070168, ENSMUST00000064488, ENSMUSG00000052557

PRO

Q8CA72

MGI

1890619

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