Reactome | Uptake of dietary cobalamins into enterocytes

Uptake of dietary cobalamins into enterocytes

Stable Identifier

R-HSA-9758881

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Uptake of dietary cobalamins into enterocytes

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The steps of transport of dietary cobalamins through the digestive tract to the distal ileum, leading to its endocytosis are annotated here. The proteins involved in these processes accommodate cobalamins including cyanocobalamin, methylcobalamin, and adenosylcobalamin. (Banerjee et al. 2021; Nielsen et al. 2012; Quadros 2010). This broad specificity is indicated by annotating R-cob(III)alamin (RCbl - CHEBI:140785) as the cargo in all of these processes.

Literature References

PubMed ID	Title	Journal	Year
19832808	Advances in the understanding of cobalamin assimilation and metabolism Quadros, EV	Br. J. Haematol.	2010
33797888	Redox-Linked Coordination Chemistry Directs Vitamin B₁₂ Trafficking Banerjee, R, Gouda, H, Pillay, S	Acc Chem Res	2021
22547309	Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway Nielsen, MJ, Rasmussen, MR, Andersen, CB, Nexø, E, Moestrup, SK	Nat Rev Gastroenterol Hepatol	2012