Reactome | Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl

Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl

Stable Identifier

R-HSA-3000243

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

lysosomal lumen

ReviewStatus

5/5

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Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl

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A lysosomal protease that is inhibited by leupeptin and sensitive to treatment with chloroquine but otherwise uncharacterized hydrolyzes cobalamin binding intrinsic factor (CBLIF, aka gastric intrinsic factor GIF) bound to cobalamins (RCbl), releasing the latter (Fyfe et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
14576052	The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless Fyfe, JC, Madsen, M, Højrup, P, Christensen, EI, Tanner, SM, de la Chapelle, A, He, Q, Moestrup, SK	Blood	2004