Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl

Stable Identifier
R-HSA-3000243
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
lysosomal lumen
ReviewStatus
5/5
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Unknown lysosomal protease degrades CBLIF:RCbl to release Cbl
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A lysosomal protease that is inhibited by leupeptin and sensitive to treatment with chloroquine but otherwise uncharacterized hydrolyzes cobalamin binding intrinsic factor (CBLIF, aka gastric intrinsic factor GIF) bound to cobalamins (RCbl), releasing the latter (Fyfe et al. 2004).

Literature References
PubMed ID Title Journal Year
14576052 The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless

Tanner, SM, Højrup, P, Fyfe, JC, He, Q, Moestrup, SK, de la Chapelle, A, Madsen, M, Christensen, EI

Blood 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

peptidase activity of unknown protease [lysosomal lumen]

Physical Entity
unknown protease [lysosomal lumen] (Homo sapiens)
Activity
peptidase activity (GO:0008233)
Authored
Jassal, B  (2013-01-24)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-01-24)
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