TCN1 binds RCbl

Stable Identifier
R-HSA-3132759
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Cobalamins in a +3 oxidation state and with various R groups (collectively, RCbl) are present in the diet as free molecules or complexed with dietary protein. The glycoprotein transcobalamin 1 (TCN1 aka haptocorrin, HC, TCII), produced by salivary glands (Morkbak et al. 2007, Wang et al. 2019), binds free RCbl and in the stomach binds RCbl freed by the initial digestion of dietary protein. In its complexed form acid-sensitive RCbl is protected from degradation in the stomach (Nielsen et al. 2012).

Literature References
PubMed ID Title Journal Year
22547309 Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway

Rasmussen, MR, Moestrup, SK, Andersen, CB, Nielsen, MJ, Nexø, E

Nat Rev Gastroenterol Hepatol 2012
17990953 Haptocorrin in humans

Morkbak, AL, Poulsen, SS, Nexo, E

Clin Chem Lab Med 2007
30777892 A deep proteome and transcriptome abundance atlas of 29 healthy human tissues

Hallström, B, Gagneur, J, Frejno, M, Hahne, H, Asplund, A, Zolg, DP, Eraslan, B, Kuster, B, Schnatbaum, K, Li, LH, Wieland, T, Hopf, T, Meng, C, Zecha, J, Schmidt, T, Ponten, F, Uhlén, M, Wilhelm, M, Wang, D

Mol Syst Biol 2019
Participants
Participates
Catalyst Activity

molecular carrier activity of TCN1 [extracellular region]

Orthologous Events
Authored
Reviewed
Created
Cite Us!