TCN1 binds Cbl

Stable Identifier
R-HSA-3132759
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Transcobalamin 1 (TCN1 aka haptocorrin, HC, TCII) is a glycoprotein produced by salivary glands in response to food ingestion (Johnston et al. 1989). TCN1 binds strongly to cobalamin (Cbl aka vitamin B12) and its essential function is protection of the acid-sensitive Cbl while it moves through the stomach. Once food is in the stomach, pepsin and the acidic pH degrade food proteins. Cbl is in its +3 oxidation state in dietary sources.

Literature References
PubMed ID Title Journal Year
2777761 Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein

Johnston, J, Bollekens, J, Allen, RH, Berliner, N

J. Biol. Chem. 1989
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