Pancreatic proteases degrade TCN1:RCbl

Stable Identifier
R-HSA-3132753
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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Pancreatic proteases degrade TCN1:RCbl
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In the proximal intestine, pancreatic enzymes degrade transcobalamin 1 (TCN1) to release cobalamins (RCbl). The two major pancreatic proteases are trypsins (PRSSs) and chymotrypsins (CTRBs) (Srikumar & Premalatha 2003, Nielsen et al. 2012).
Literature References
PubMed ID Title Journal Year
22900303 Effect of gastrointestinal proteases on purified human intrinsic factor-vitamin B12 (IF-B12) complex

Premalatha, R, Srikumar, K

Indian J. Biochem. Biophys. 2003
22547309 Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway

Rasmussen, MR, Moestrup, SK, Andersen, CB, Nielsen, MJ, Nexø, E

Nat Rev Gastroenterol Hepatol 2012
Participants
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Output
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as an event of
Catalyst Activity

serine-type peptidase activity of PRSS1,3,CTRB1,2 [extracellular region]

Physical Entity
PRSS1,3,CTRB1,2 [extracellular region] (Homo sapiens)
Activity
serine-type peptidase activity (GO:0008236)
Orthologous Events
Pancreatic proteases degrade TCN1:RCbl (Bos taurus)
Pancreatic proteases degrade TCN1:RCbl (Canis familiaris)
Pancreatic proteases degrade TCN1:RCbl (Sus scrofa)
Pancreatic proteases degrade TCN1:RCbl (Xenopus tropicalis)
Authored
Jassal, B  (2013-02-13)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-02-13)
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