Pancreatic proteases degrade TCN1:Cbl

Stable Identifier
R-HSA-3132753
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

In the proximal intestine, pancreatic enzymes degrade transcobalamin 1 (TCN1) to release cobalamin (Cbl). The two major pancreatic proteases are trypsins (PRSSs) and chymotrypsins (CTRBs) (Srikumar & Premalatha 2003, Nielsen et al. 2012).

Literature References
PubMed ID Title Journal Year
22547309 Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway

Nielsen, MJ, Rasmussen, MR, Andersen, CB, Nexø, E, Moestrup, SK

Nat Rev Gastroenterol Hepatol 2012
22900303 Effect of gastrointestinal proteases on purified human intrinsic factor-vitamin B12 (IF-B12) complex

Srikumar, K, Premalatha, R

Indian J. Biochem. Biophys. 2003
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type peptidase activity of PRSS1,3,CTRB1,2 [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created