CBLIF binds RCbl

Stable Identifier
R-HSA-3000120
Type
Reaction [transition]
Species
Homo sapiens
Compartment
extracellular region
ReviewStatus
5/5
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CBLIF binds RCbl
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Gastric parietal cells secrete cobalamin binding intrinsic factor (CBLIF, aka gastric intrinsic factor GIF) which binds tightly to free cobalamins (RCbl) released from transcobalamin (TCN1, haptocorrin) in the proximal intestine (Matthews et al. 2007). RCbl must bind to CBLIF to be absorbed from the small intestine.

Literature References
PubMed ID Title Journal Year
17954916 Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution

Gordon, MM, Mathews, FS, Ealick, SE, Alpers, DH, Chen, Z, Rajashankar, KR, Sukumar, N

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Input
Output
Participates
as an event of
Catalyst Activity

cargo receptor ligand activity of CBLIF [extracellular region]

Physical Entity
CBLIF [extracellular region] (Homo sapiens)
Activity
cargo receptor ligand activity (GO:0140355)
Orthologous Events
CBLIF binds RCbl (Bos taurus)
CBLIF binds RCbl (Canis familiaris)
CBLIF binds RCbl (Danio rerio)
CBLIF binds RCbl (Drosophila melanogaster)
CBLIF binds RCbl (Mus musculus)
CBLIF binds RCbl (Rattus norvegicus)
CBLIF binds RCbl (Sus scrofa)
CBLIF binds RCbl (Xenopus tropicalis)
Authored
Jassal, B  (2013-01-24)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-01-24)
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