GIF binds Cbl

Stable Identifier
R-HSA-3000120
Type
Reaction [binding]
Species
Homo sapiens
Compartment
extracellular region
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GIF binds Cbl
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Gastric parietal cells secrete gastric intrinsic factor (GIF) which binds tightly to free cobalamin (Cbl) released from transcobalamin (TCN1, haptocorrin) in the proximal intestine (Matthews et al. 2007). Cbl must bind to GIF to be absorbed from the small intestine.

Literature References
PubMed ID Title Journal Year
17954916 Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution

Mathews, FS, Gordon, MM, Chen, Z, Rajashankar, KR, Ealick, SE, Alpers, DH, Sukumar, N

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Input
Output
Participant Of
hasEvent
Orthologous Events
GIF binds Cbl (Bos taurus)
GIF binds Cbl (Danio rerio)
GIF binds Cbl (Drosophila melanogaster)
GIF binds Cbl (Gallus gallus)
GIF binds Cbl (Mus musculus)
GIF binds Cbl (Rattus norvegicus)
GIF binds Cbl (Sus scrofa)
GIF binds Cbl (Xenopus tropicalis)
Authored
Jassal, B  (2013-01-24)
Reviewed
D'Eustachio, P  (2013-04-15)
Created
Jassal, B  (2013-01-24)