GIF binds Cbl

Stable Identifier
R-HSA-3000120
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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Gastric parietal cells secrete gastric intrinsic factor (GIF) which binds tightly to free cobalamin (Cbl) released from transcobalamin (TCN1, haptocorrin) in the proximal intestine (Matthews et al. 2007). Cbl must bind to GIF to be absorbed from the small intestine.

Literature References
PubMed ID Title Journal Year
17954916 Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution

Mathews, FS, Gordon, MM, Chen, Z, Rajashankar, KR, Ealick, SE, Alpers, DH, Sukumar, N

Proc. Natl. Acad. Sci. U.S.A. 2007
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