CBLIF binds RCbl

Stable Identifier
R-HSA-3000120
Type
Reaction
Species
Homo sapiens
Compartment
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Gastric parietal cells secrete cobalamin binding intrinsic factor (CBLIF, aka gastric intrinsic factor GIF) which binds tightly to free cobalamins (RCbl) released from transcobalamin (TCN1, haptocorrin) in the proximal intestine (Matthews et al. 2007). RCbl must bind to CBLIF to be absorbed from the small intestine.

Literature References
PubMed ID Title Journal Year
17954916 Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution

Gordon, MM, Mathews, FS, Ealick, SE, Alpers, DH, Chen, Z, Rajashankar, KR, Sukumar, N

Proc. Natl. Acad. Sci. U.S.A. 2007
Participants
Participates
Catalyst Activity

molecular carrier activity of CBLIF [extracellular region]

Orthologous Events
Authored
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