Reactome | CBLIF binds RCbl

CBLIF binds RCbl

Stable Identifier

R-HSA-3000120

Type

Reaction

Species

Homo sapiens

Compartment

extracellular region

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Gastric parietal cells secrete cobalamin binding intrinsic factor (CBLIF, aka gastric intrinsic factor GIF) which binds tightly to free cobalamins (RCbl) released from transcobalamin (TCN1, haptocorrin) in the proximal intestine (Matthews et al. 2007). RCbl must bind to CBLIF to be absorbed from the small intestine.

Literature References

PubMed ID	Title	Journal	Year
17954916	Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution Gordon, MM, Mathews, FS, Ealick, SE, Alpers, DH, Chen, Z, Rajashankar, KR, Sukumar, N	Proc. Natl. Acad. Sci. U.S.A.	2007