Reactome | GIF binds Cbl

GIF binds Cbl

Stable Identifier

R-HSA-3000120

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region

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Gastric parietal cells secrete gastric intrinsic factor (GIF) which binds tightly to free cobalamin (Cbl) released from transcobalamin (TCN1, haptocorrin) in the proximal intestine (Matthews et al. 2007). Cbl must bind to GIF to be absorbed from the small intestine.

Literature References

PubMed ID	Title	Journal	Year
17954916	Crystal structure of human intrinsic factor: cobalamin complex at 2.6-A resolution Mathews, FS, Gordon, MM, Chen, Z, Rajashankar, KR, Ealick, SE, Alpers, DH, Sukumar, N	Proc. Natl. Acad. Sci. U.S.A.	2007