CUBN:AMN-mediated CBLIF:RCbl uptake and delivery to lysosome

Stable Identifier
R-HSA-3000137
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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The cubilin protein:amnionless (CUBN:AMN) complex mediates the endocytosis of gastric internal factor complexes with cobalamins (CBLIF:RCbl) into coated vesicles of mucosal cells of the distal ileum. There, the CBLIF:RCbl complex dissociates from CUBN:AMN, which returns to the plasma membrane while CBLIF:RCbl is delivered to lysosomes (Fyfe et al. 2004).

Literature References
PubMed ID Title Journal Year
14576052 The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless

Tanner, SM, Højrup, P, Fyfe, JC, He, Q, Moestrup, SK, de la Chapelle, A, Madsen, M, Christensen, EI

Blood 2004
Participants
Participates
Catalyst Activity

cargo receptor activity of CUBN:AMN:CBLIF:RCbl [plasma membrane]

Orthologous Events
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