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NDUFS7 [mitochondrial matrix]
Stable Identifier
R-HSA-6788521
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
NADH-ubiquinone oxidoreductase 20 kDa subunit
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Respiratory electron transport (Homo sapiens)
Complex I biogenesis (Homo sapiens)
IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
Intermediate 1 binds HP subcomplex to form Intermediate 2 (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
ND4, ND5 bind the 550kDa complex to form the 815kDa complex (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
NDUF subunits bind to form the IP subcomplex (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
NUBPL transfers 4Fe-4S to Complex I subunits (Homo sapiens)
NDUF subunits [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
NDUF:4Fe-4S subunits [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)
980kDa complex [mitochondrial inner membrane] (Homo sapiens)
815kDa complex [mitochondrial inner membrane] (Homo sapiens)
550kDa complex [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 [mitochondrial inner membrane] (Homo sapiens)
IP subcomplex [mitochondrial matrix] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
Complex I oxidises NADH to NAD+, reduces CoQ to CoQH2 (Homo sapiens)
Complex I [mitochondrial inner membrane] (Homo sapiens)
815kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
550kDa complex (-MCIA, NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
315kDa subcomplex (-NDUFAF3,4,5,6,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 2 (-NDUFAF3,4,7,TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
Intermediate 1 (-NDUFAF3,4,7, TIMMDC1) [mitochondrial inner membrane] (Homo sapiens)
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
NDUFS7 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75251 NDUFS7
Gene Names
NDUFS7
Chain
transit peptide:1-38, chain:39-213
Reference Genes
BioGPS Gene:374291 NDUFS7
COSMIC (genes):NDUFS7 NDUFS7
CTD Gene:374291 NDUFS7
dbSNP Gene:374291 NDUFS7
ENSEMBL:ENSG00000115286 NDUFS7
HGNC:7714 NDUFS7
KEGG:hsa:374291 NDUFS7
Monarch:374291 NDUFS7
NCBI Gene:374291 NDUFS7
OMIM:601825 NDUFS7
UCSC:O75251 NDUFS7
Reference Transcript
RefSeq:NM_024407.4 NDUFS7
Other Identifiers
11723062_a_at
11746586_a_at
11759833_at
11760482_x_at
16856543
211752_PM_s_at
211752_s_at
2363810
242168_PM_at
242168_at
2440863
31638_at
3280995
3508167
374291
3755358
3815728
3815729
3815810
3815811
3815812
3815813
3815814
3815815
3815817
3815818
3815819
3815820
3815821
3815822
3815823
3815824
3815825
3815826
3815827
3815828
3815829
3815830
3815831
3815832
3815833
8024273
84449_f_at
84451_f_at
A_23_P165086
A_23_P165090
A_33_P3320808
GE61973
GO:0002020
GO:0003824
GO:0003954
GO:0005215
GO:0005515
GO:0005739
GO:0005743
GO:0005759
GO:0006091
GO:0006120
GO:0008137
GO:0009060
GO:0015990
GO:0016491
GO:0016655
GO:0032981
GO:0042776
GO:0043025
GO:0043226
GO:0045271
GO:0046872
GO:0048038
GO:0051536
GO:0051539
GO:0055085
GO:0055086
GO:0065003
GO:0097060
GO:1901135
GO:1902600
HMNXSV003024567
HMNXSV003049601
Hs.150913.0.S1_3p_at
ILMN_1669966
PH_hs_0040636
TC01001143.hg
TC01001404.hg
TC01003428.hg
TC10001099.hg
TC13000535.hg
TC17001431.hg
TC19000037.hg
g13543602_3p_s_at
Participates
as a member of
NDUF subunits [mitochondrial matrix] (Homo sapiens)
as a component of
NDUFS7:4Fe-4S [mitochondrial matrix] (Homo sapiens)
Inferred To
ndufs7 [mitochondrial matrix]
(Xenopus tropicalis)
Ndufs7 [mitochondrial matrix]
(Rattus norvegicus)
ND-20 [mitochondrial matrix]
(Drosophila melanogaster)
Ghost homologue of NDUFS7 [mitochondrial matrix]
(Danio rerio)
NDUFS7 [mitochondrial matrix]
(Bos taurus)
NDUFS7 [mitochondrial matrix]
(Caenorhabditis elegans)
NDUFS7 [mitochondrial matrix]
(Canis familiaris)
NDUFS7 [mitochondrial matrix]
(Dictyostelium discoideum)
NDUFS7 [mitochondrial matrix]
(Gallus gallus)
NDUFS7 [mitochondrial matrix]
(Mus musculus)
NDUFS7 [mitochondrial matrix]
(Sus scrofa)
Cross References
OpenTargets
ENSG00000115286
ENSEMBL
ENSP00000233627
,
ENST00000546283
,
ENSP00000364262
,
ENST00000313408
,
ENSP00000440348
,
ENSG00000115286
,
ENST00000233627
HPA
ENSG00000115286-NDUFS7
GeneCards
NDUFS7
PRO
O75251
Pharos - Targets
O75251
GlyGen
O75251
Orphanet
NDUFS7
HMDB Protein
HMDBP00180
PDB
5XTI
,
5XTH
,
5XTD
,
5XTB
Interactors (28)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9P032 NDUFAF4
1
NDUFAF4 [mitochondrial inner membrane]
(R-HSA-5689124)
0.725
9
UniProt:O75489 NDUFS3
2
NDUFS3 [mitochondrial matrix]
(R-HSA-163927)
NDUFS3 [cytosol]
(R-HSA-9714751)
0.725
9
UniProt:P36776 LONP1
1
LONP1 [mitochondrial matrix]
(R-HSA-9838000)
0.643
5
UniProt:Q9UI09 NDUFA12
1
NDUFA12 [mitochondrial inner membrane]
(R-HSA-59864)
0.643
5
UniProt:Q9P0J0 NDUFA13
8
NDUFA13 [mitochondrial inner membrane]
(R-HSA-59936)
NDUFA13(41-49) [mitochondrial inner membrane]
(R-HSA-9839958)
NDUFA13(100-108) [mitochondrial inner membrane]
(R-HSA-9839959)
NDUFA13(109-144) [mitochondrial inner membrane]
(R-HSA-9839968)
NDUFA13(2-19) [mitochondrial inner membrane]
(R-HSA-9839966)
NDUFA13(69-99) [mitochondrial inner membrane]
(R-HSA-9839964)
NDUFA13(20-40) [mitochondrial inner membrane]
(R-HSA-9839963)
NDUFA13(50-68) [mitochondrial inner membrane]
(R-HSA-9839961)
0.643
4
UniProt:Q5TEU4 NDUFAF5
1
NDUFAF5 [mitochondrial inner membrane]
(R-HSA-5689127)
0.643
5
UniProt:P10809 HSPD1
6
HSPD1(1-26) [mitochondrial matrix]
(R-HSA-8986171)
HSPD1(1-573) [mitochondrial inner membrane]
(R-HSA-1299442)
HSPD1 [mitochondrial inner membrane]
(R-HSA-1299455)
HSPD1(1-573) [mitochondrial intermembrane space]
(R-HSA-1267963)
HSPD1(1-573) [cytosol]
(R-HSA-1267989)
HSPD1 [mitochondrial matrix]
(R-HSA-1299448)
0.615
5
UniProt:P49590 HARS2
1
HARS2 [mitochondrial matrix]
(R-HSA-379581)
0.527
2
UniProt:Q5ST30 VARS2
1
VARS2 [mitochondrial matrix]
(R-HSA-379626)
0.527
3
UniProt:Q9BU61 NDUFAF3
1
NDUFAF3 [mitochondrial inner membrane]
(R-HSA-5689126)
0.527
3
UniProt:P03915 MT-ND5
1
MT-ND5 [mitochondrial inner membrane]
(R-HSA-60565)
0.527
2
UniProt:Q96GW9 MARS2
1
MARS2 [mitochondrial matrix]
(R-HSA-379555)
0.527
3
UniProt:P31327 CPS1
1
CPS1 [mitochondrial matrix]
(R-HSA-70544)
0.527
4
UniProt:O75380 NDUFS6
1
NDUFS6 [mitochondrial inner membrane]
(R-HSA-163922)
0.527
5
UniProt:Q9NPL8 TIMMDC1
1
TIMMDC1 [mitochondrial inner membrane]
(R-HSA-5689720)
0.527
2
UniProt:Q96I59 NARS2
1
NARS2 [mitochondrial matrix]
(R-HSA-379585)
0.527
4
UniProt:Q4G176 ACSF3
1
ACSF3 [mitochondrial matrix]
(R-HSA-5696011)
0.527
3
UniProt:P03905 MT-ND4
1
MT-ND4 [mitochondrial inner membrane]
(R-HSA-60561)
0.527
2
UniProt:O43920 NDUFS5
1
NDUFS5 [mitochondrial inner membrane]
(R-HSA-60226)
0.527
2
UniProt:Q9NTG7 SIRT3
2
SIRT3(?-399) [mitochondrial matrix]
(R-HSA-1605416)
SIRT3 [nucleoplasm]
(R-HSA-9622879)
0.527
4
UniProt:Q5JTZ9 AARS2
1
AARS2 [mitochondrial matrix]
(R-HSA-379653)
0.527
3
UniProt:Q9NSE4 IARS2
1
IARS2 [mitochondrial matrix]
(R-HSA-379571)
0.527
4
UniProt:Q9BQ95 ECSIT
2
ECSIT [cytosol]
(R-HSA-168064)
ECSIT [mitochondrial inner membrane]
(R-HSA-5689047)
0.527
4
UniProt:Q9H3L0 MMADHC
8
MMADHC [cytosol]
(R-HSA-3149529)
MMADHC R250* [cytosol]
(R-HSA-3318608)
MMADHC T182N [cytosol]
(R-HSA-3318599)
MMADHC L259P [cytosol]
(R-HSA-3318587)
MMADHC Y249C [cytosol]
(R-HSA-3318584)
MMADHC Y140* [cytosol]
(R-HSA-3318633)
MMADHC R54* [cytosol]
(R-HSA-3318620)
MMADHC S20* [cytosol]
(R-HSA-3318573)
0.527
2
UniProt:P46199 MTIF2
1
MTIF2 [mitochondrial matrix]
(R-HSA-5368271)
0.527
3
UniProt:Q8NE62 CHDH
1
CHDH [mitochondrial inner membrane]
(R-HSA-6798195)
0.527
2
UniProt:Q15031 LARS2
1
LARS2(1-?) [mitochondrial matrix]
(R-HSA-379635)
0.527
4
UniProt:O43181 NDUFS4
1
NDUFS4 [mitochondrial inner membrane]
(R-HSA-163946)
0.527
3
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