FOXO3,FOXO6,(FOXO1) binds CAT gene promoter

Stable Identifier
Reaction [binding]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Based on studies with mouse FOXO proteins, FOXO3 (Rangarajan et al. 2015, Song et al. 2016) and FOXO6 (Kim et al. 2014) bind forkhead box elements in the promoter of the CAT gene, encoding the enzyme catalase. Catalase converts hydrogen peroxide to water and oxygen, thus protecting cells from the oxidative stress. FOXO1 positively regulates CAT gene transcription (Awad et al. 2014, Liao et al. 2016, Guo et al. 2016) and is probably able to bind to forkhead box elements in the CAT gene promoter.
FOXO3-mediated upregulation of the CAT gene transcription is positively regulated by SIRT3 histone deacetylase, which deacetylates FOXO3 under conditions of oxidative stress and increases nuclear localization of FOXO3 (Sundaresan et al. 2009, Rangarajan et al. 2015, Yang et al. 2016).

Participant Of
This event is regulated
Positively by
Inferred From
Cite Us!