Reactome | TRIB1 [cytosol]

TRIB1 [cytosol]

Stable Identifier

R-HSA-9621338

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tribbles homolog 1, TRIB1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Nuclear Events (kinase and transcription factor activation) (Homo sapiens)
        
        NGF-stimulated transcription (Homo sapiens)
        
        TRIB1 gene expression (Homo sapiens)
        
        TRIB1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q96RU8 TRIB1

Gene Names

TRIB1, C8FW, GIG2, TRB1

Chain

chain:1-372

Reference Genes

BioGPS Gene:10221 TRIB1

COSMIC (genes):TRIB1 TRIB1

CTD Gene:10221 TRIB1

dbSNP Gene:10221 TRIB1

ENSEMBL:ENSG00000173334 TRIB1

HGNC:16891 TRIB1

KEGG:hsa:10221 TRIB1

Monarch:10221 TRIB1

NCBI Gene:10221 TRIB1

OMIM:609461 TRIB1

UCSC:Q96RU8 TRIB1

Reference Transcript

Other Identifiers

10221

11716048_at

11716049_a_at

17072601

202241_PM_at

202241_at

239818_PM_x_at

239818_x_at

3115014

3115015

3115017

3115018

3115019

3115020

3115021

3115022

35597_at

57239_at

8148304

82665_at

AJ000480_at

A_14_P106006

A_14_P107944

A_24_P252497

GE55128

GE55750

GO:0003824

GO:0004672

GO:0004860

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005829

GO:0006355

GO:0006468

GO:0006469

GO:0007254

GO:0014912

GO:0016740

GO:0031434

GO:0031625

GO:0031665

GO:0032436

GO:0032496

GO:0043226

GO:0043405

GO:0043433

GO:0045645

GO:0045651

GO:0045659

GO:0048662

GO:0055106

GO:0061629

GO:0098772

GO:0140096

HMNXSV003023355

HMNXSV003042336

Hs.188886.0.A1_3p_at

Hs.188886.0.A1_3p_x_at

ILMN_1803811

PH_hs_0026012

TC08000733.hg

g13399327_3p_at

Participates

as an output of

TRIB1 gene expression (Homo sapiens)

Cross References

RefSeq

NP_001269914.1, NP_079471.1

Guide to Pharmacology - Targets

2249

ENSEMBL

ENSP00000312150, ENST00000520847, ENSP00000429063, ENST00000311922

OpenTargets

ENSG00000173334

HPA

ENSG00000173334-TRIB1

PRO

Q96RU8

Pharos - Targets

Q96RU8

GlyGen

Q96RU8

PDB

5IGO, 5CEM, 6DC0, 5IGQ, 5CEK

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N2I9 STK40			0.744	6
UniProt:Q7L5Y6 DET1	1	DET1 [cytosol] (R-HSA-976007)	0.643	4
UniProt:P51965 UBE2E1	4	Ub-C131-UBE2E1 [nucleoplasm] (R-HSA-8864185) Ub-C131-UBE2E1 [cytosol] (R-HSA-8864219) UBE2E1 [nucleoplasm] (R-HSA-174063) UBE2E1 [cytosol] (R-HSA-174100)	0.527	2
UniProt:Q9BY49 PECR	2	PECR [cytosol] (R-HSA-9033155) PECR [peroxisomal membrane] (R-HSA-6809577)	0.527	2
UniProt:Q92519 TRIB2			0.527	2
UniProt:Q9BUE6 ISCA1	1	ISCA1 [mitochondrial matrix] (R-HSA-5691212)	0.527	2
UniProt:P15408 FOSL2			0.527	3
UniProt:P01100 FOS	2	FOS [nucleoplasm] (R-HSA-450216) p-T325,T331,S362,S374-FOS [nucleoplasm] (R-HSA-450283)	0.527	2
UniProt:Q8NHY2 RFWD2	3	p-S387-RFWD2 [cytosol] (R-HSA-349439) RFWD2 [nucleoplasm] (R-HSA-349454) p-S387-RFWD2 [nucleoplasm] (R-HSA-349450)	0.527	3

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