Reactome | Ub-C131-UBE2E1 [nucleoplasm]

Ub-C131-UBE2E1 [nucleoplasm]

Stable Identifier

R-HSA-8864185

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 E1 ecNumber evidence="9"2.3.2.23/ecNumber, UB2E1_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
        
        Ub:E2 (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        Ub-C131-UBE2E1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51965 UBE2E1

Gene Names

UBE2E1, UBCH6

Chain

initiator methionine:, chain:2-193

Reference Genes

BioGPS Gene:7324 UBE2E1

COSMIC (genes):UBE2E1 UBE2E1

CTD Gene:7324 UBE2E1

dbSNP Gene:7324 UBE2E1

ENSEMBL:ENSG00000170142 UBE2E1

ENSEMBL_homo_sapiens_GENE:ENSG00000170142.12 UBE2E1

HGNC:12477 UBE2E1

KEGG Gene (Homo sapiens):7324 UBE2E1

Monarch:7324 UBE2E1

NCBI Gene:7324 UBE2E1

OMIM:602916 UBE2E1

UCSC:P51965 UBE2E1

Reference Transcript

Other Identifiers

11757878_s_at

212519_PM_at

212519_at

2614062

2614063

2614064

2614066

2614067

2614071

2614073

2614100

2614101

2614103

2614104

2614105

2614106

37358_at

7324

8078262

A_14_P125715

A_23_P6963

GE60159

GO:0000151

GO:0000166

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0006351

GO:0006355

GO:0006511

GO:0016567

GO:0016740

GO:0019787

GO:0030163

GO:0032020

GO:0032446

GO:0036211

GO:0042296

GO:0043226

GO:0045944

GO:0061631

GO:0070936

GO:0140096

HMNXSV003041722

HMNXSV003056849

Hs.7766.0.A2_3p_at

ILMN_1806778

ILMN_2371685

PH_hs_0009892

TC03000125.hg

Participates

as a member of

Ub-conjugated E2 enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)

Other forms of this molecule

Ub-C131-UBE2E1 [cytosol]

UBE2E1 [nucleoplasm]

UBE2E1 [cytosol]

Inferred To

ube2e2 [nucleoplasm] (Danio rerio)

Ub-C131-UBE2E1 [nucleoplasm] (Dictyostelium discoideum)

Ub-C131-UBE2E1 [nucleoplasm] (Gallus gallus)

Ub-C131-UBE2E1 [nucleoplasm] (Sus scrofa)

UBE2E1 [nucleoplasm] (Bos taurus)

UBE2E1 [nucleoplasm] (Canis familiaris)

ubc-24 [nucleoplasm] (Caenorhabditis elegans)

Ube2e1 [nucleoplasm] (Mus musculus)

Ube2e1 [nucleoplasm] (Rattus norvegicus)

Ubc2 [nucleoplasm] (Drosophila melanogaster)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 131

Coordinate

131

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_872607.1, NP_003332.1, NP_001189405.1

OpenTargets

ENSG00000170142

GeneCards

P51965

HPA

ENSG00000170142-UBE2E1

Ensembl

ENST00000306627, ENSG00000170142, ENSP00000329113, ENSP00000303709, ENST00000424381, ENST00000346855, ENSP00000411351

PRO

P51965

Pharos - Targets

P51965

HMDB Protein

HMDBP00620

PDB

6FGA, 4JJQ, 3BZH, 8IYA, 5LBN, 1XR9

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.553	2
UniProt:Q96RU8 TRIB1	1	TRIB1 [cytosol] (R-HSA-9621338)	0.527	2