Reactome | Ub-C131-UBE2E1 [cytosol]

Ub-C131-UBE2E1 [cytosol]

Stable Identifier

R-HSA-8864219

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - E3 ubiquitin ligases ubiquitinate target proteins (Homo sapiens)
      - RNF181 binds BCL10 and Ubiquitin:E2 (Homo sapiens)
        
        RNF181:BCL10:Ub:E2 [cytoplasm] (Homo sapiens)
        
        Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
        
        Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
        
        Ub-C131-UBE2E1 [cytosol] (Homo sapiens)
        
        Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
        
        Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
        
        Ub-C131-UBE2E1 [cytosol] (Homo sapiens)
      - RNF181 polyubiquinates BCL10 (Homo sapiens)
        
        RNF181:BCL10:Ub:E2 [cytoplasm] (Homo sapiens)
        
        Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
        
        Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
        
        Ub-C131-UBE2E1 [cytosol] (Homo sapiens)
        
        Ub:UBE2D1,UBE2D2,UBE2D3, UBE2E1,UBE2N [cytosol] (Homo sapiens)
        
        Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)
        
        Ub-C131-UBE2E1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
15545318	Ubiquitin charging of human class III ubiquitin-conjugating enzymes triggers their nuclear import Plafker, KS, Macara, IG, Weissman, AM, Plafker, SM	J. Cell Biol.	2004

External Reference Information

External Reference

UniProt:P51965 UBE2E1

Gene Names

UBE2E1, UBCH6

Chain

initiator methionine:, chain:2-193

Reference Genes

BioGPS Gene:7324 UBE2E1

COSMIC (genes):UBE2E1 UBE2E1

CTD Gene:7324 UBE2E1

dbSNP Gene:7324 UBE2E1

ENSEMBL:ENSG00000170142 UBE2E1

HGNC:12477 UBE2E1

KEGG:hsa:7324 UBE2E1

Monarch:7324 UBE2E1

NCBI Gene:7324 UBE2E1

OMIM:602916 UBE2E1

UCSC:P51965 UBE2E1

Reference Transcript

Other Identifiers

11757878_s_at

11761359_at

212519_PM_at

212519_at

2614062

2614063

2614064

2614065

2614066

2614067

2614068

2614069

2614070

2614071

2614072

2614073

2614090

2614100

2614101

2614102

2614103

2614104

2614105

2614106

37358_at

7324

8078262

A_14_P125715

A_23_P6963

GE60159

GO:0000151

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005829

GO:0006355

GO:0006511

GO:0016567

GO:0016740

GO:0019787

GO:0032020

GO:0042296

GO:0043226

GO:0045944

GO:0061631

GO:0070936

GO:0140096

HMNXSV003041722

HMNXSV003056849

Hs.7766.0.A2_3p_at

ILMN_1806778

ILMN_2371685

PH_hs_0009892

TC03000125.hg

Participates

as a member of

Ub-UBE2D1,2,3,UBE2E1,UBE2N [cytosol] (Homo sapiens)

Other forms of this molecule

Ub-C131-UBE2E1 [nucleoplasm]

UBE2E1 [nucleoplasm]

UBE2E1 [cytosol]

Inferred To

Ub-C131-UBE2E1 [cytosol] (Dictyostelium discoideum)

Ub-C131-UBE2E1 [cytosol] (Gallus gallus)

Ub-C131-UBE2E1 [cytosol] (Sus scrofa)

Ube2e1 [cytosol] (Mus musculus)

Ube2e1 [cytosol] (Rattus norvegicus)

UBE2E1 [cytosol] (Bos taurus)

UBE2E1 [cytosol] (Canis familiaris)

ube2e2 [cytosol] (Danio rerio)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 131

Coordinate

131

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_003332.1, NP_001189405.1, NP_872607.1

ENSEMBL

ENSP00000411351, ENSP00000303709, ENST00000306627, ENSP00000329113, ENST00000346855, ENST00000424381

OpenTargets

ENSG00000170142

HPA

ENSG00000170142-UBE2E1

PRO

P51965

Pharos - Targets

P51965

HMDB Protein

HMDBP00620

PDB

1XR9, 3BZH, 4JJQ, 8IYA, 5LBN, 6FGA

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6ZNA4 RNF111	2	RNF111 [cytosol] (R-HSA-975981) RNF111 [nucleoplasm] (R-HSA-2186765)	0.553	2
UniProt:Q96RU8 TRIB1	1	TRIB1 [cytosol] (R-HSA-9621338)	0.527	2