TRIB1 gene expression

Stable Identifier
R-HSA-9621386
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRIB1 gene expression
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRIB1 is an adapter protein that interacts with COP1 ubiquitin ligase to regulate protein degradation (Uljon et al, 2016). Studies in rat PC12 cells identified TRIB1 as a target gene of EGR1 in response to sustained NGF signaling, and EGR1 was shown to bind to cognate sites in the promoter as assessed by ChIP (Mullenbrock et al, 2011; Adams et al, 2017).

Literature References
PubMed ID Title Journal Year
27041596 Structural Basis for Substrate Selectivity of the E3 Ligase COP1

Uljon, S, Xu, X, Durzynska, I, Stein, S, Adelmant, G, Marto, JA, Pear, WS, Blacklow, SC

Structure 2016
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Adams, KW, Kletsov, S, Lamm, RJ, Elman, JS, Mullenbrock, S, Cooper, GM

PLoS ONE 2017
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Mullenbrock, S, Shah, J, Cooper, GM

J. Biol. Chem. 2011
Participants
Input
Output
Participant Of
hasEvent
This event is regulated
Positively by
Authored
Rothfels, K  (2019-08-16)
Reviewed
Aletta, J M  (2020-01-17)
Created
Rothfels, K  (2018-09-26)