TRIB1 gene expression

Stable Identifier
Reaction [omitted]
Homo sapiens
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TRIB1 is an adapter protein that interacts with COP1 ubiquitin ligase to regulate protein degradation (Uljon et al, 2016). Studies in rat PC12 cells identified TRIB1 as a target gene of EGR1 in response to sustained NGF signaling, and EGR1 was shown to bind to cognate sites in the promoter as assessed by ChIP (Mullenbrock et al, 2011; Adams et al, 2017).

Literature References
PubMed ID Title Journal Year
28076410 Role for Egr1 in the Transcriptional Program Associated with Neuronal Differentiation of PC12 Cells

Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S

PLoS ONE 2017
27041596 Structural Basis for Substrate Selectivity of the E3 Ligase COP1

Marto, JA, Blacklow, SC, Xu, X, Pear, WS, Uljon, S, Adelmant, G, Stein, S, Durzynska, I

Structure 2016
22065583 Global expression analysis identified a preferentially nerve growth factor-induced transcriptional program regulated by sustained mitogen-activated protein kinase/extracellular signal-regulated kinase (ERK) and AP-1 protein activation during PC12 cell differentiation

Cooper, GM, Mullenbrock, S, Shah, J

J. Biol. Chem. 2011
This event is regulated