TRIB1 is an adapter protein that interacts with COP1 ubiquitin ligase to regulate protein degradation (Uljon et al, 2016). Studies in rat PC12 cells identified TRIB1 as a target gene of EGR1 in response to sustained NGF signaling, and EGR1 was shown to bind to cognate sites in the promoter as assessed by ChIP (Mullenbrock et al, 2011; Adams et al, 2017).
Kletsov, S, Cooper, GM, Elman, JS, Adams, KW, Lamm, RJ, Mullenbrock, S
Marto, JA, Blacklow, SC, Xu, X, Pear, WS, Uljon, S, Adelmant, G, Stein, S, Durzynska, I
Cooper, GM, Mullenbrock, S, Shah, J
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