ROS oxidize FOXO4 cysteine residues

Stable Identifier
R-HSA-9617660
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Reactive oxygen species (ROS) oxidize cysteine residue(s) of FOXO4. There are five cysteine residues in FOXO4, of which two residues, C31 (corresponds to C27 in mouse Foxo4) and C481 (corresponds to C477 of mouse Foxo4) are conserved in other FOXO family members. Oxidation of C481 of FOXO4 has the most significant functional implications (Dansen et al. 2009).

Participants
Participant Of
Inferred From
Authored
Reviewed
Created