ROS oxidize FOXO4 cysteine residues

Stable Identifier
R-HSA-9617660
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ROS oxidize FOXO4 cysteine residues
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Reactive oxygen species (ROS) oxidize cysteine residue(s) of FOXO4. There are five cysteine residues in FOXO4, of which two residues, C31 (corresponds to C27 in mouse Foxo4) and C481 (corresponds to C477 of mouse Foxo4) are conserved in other FOXO family members. Oxidation of C481 of FOXO4 has the most significant functional implications (Dansen et al. 2009).
Participants
Input
Output
Participates
as an event of
Inferred From
ROS oxidize Foxo4 cysteine residues (Mus musculus)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-08-30)
Cite Us!