TXN disrupts FOXO4 complex with EP300

Stable Identifier
R-HSA-9617735
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TXN disrupts FOXO4 complex with EP300
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Thioredoxin (TXN) reduces oxidized FOXO4 and disrupts interaction between FOXO4 and EP300 (p300). TXN-mediated disruption of FOXO4:EP300 complexes is negatively regulated by TXNIP (TBP-2), a TXN binding protein (Dansen et al. 2009).
Participants
Input
Output
Participates
as an event of
Catalyst Activity

thioredoxin-disulfide reductase (NADPH) activity of TXN [nucleoplasm]

Physical Entity
TXN [nucleoplasm] (Homo sapiens)
Activity
thioredoxin-disulfide reductase (NADPH) activity (GO:0004791)
This event is regulated
Negatively by
Regulator
TXNIP [nucleoplasm] (Homo sapiens)
Inferred From
TXN disrupts Foxo4 comples with EP300 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-08-30)
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