TXN disrupts FOXO4 complex with EP300

Stable Identifier
R-HSA-9617735
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Thioredoxin (TXN) reduces oxidized FOXO4 and disrupts interaction between FOXO4 and EP300 (p300). TXN-mediated disruption of FOXO4:EP300 complexes is negatively regulated by TXNIP (TBP-2), a TXN binding protein (Dansen et al. 2009).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thioredoxin-disulfide reductase activity of TXN [nucleoplasm]
Physical Entity
Activity
This event is regulated
Negatively by
Inferred From
Authored
Reviewed
Created