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CREBBP acetylates FOXO1
Stable Identifier
R-HSA-9626945
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
FOXO-mediated transcription (Homo sapiens)
Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
CREBBP acetylates FOXO1 (Homo sapiens)
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Based on experiments using recombinant human CREBBP and recombinant mouse Foxo1, CREBBP phosphorylates FOXO1 on conserved lysine residues K245, K248 and K265 (these residues correspond to K242, K245 and K262, respectively, in mouse Foxo1) (Daitoku et al. 2004).
Participants
Input
x 3
Ac-CoA [nucleoplasm]
FOXO1:CREBBP [nucleoplasm]
(Homo sapiens)
Output
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(Homo sapiens)
x 3
CoA-SH [nucleoplasm]
CREBBP [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Regulation of FOXO transcriptional activity by acetylation (Homo sapiens)
Catalyst Activity
peptide-lysine-N-acetyltransferase activity of FOXO1:CREBBP [nucleoplasm]
Physical Entity
FOXO1:CREBBP [nucleoplasm]
(Homo sapiens)
Activity
peptide-lysine-N-acetyltransferase activity (GO:0061733)
Inferred From
CREBBP acetylates Foxo1 (Homo sapiens)
Authored
Orlic-Milacic, M (2018-10-31)
Reviewed
Bertaggia, E (2018-10-26)
Created
Orlic-Milacic, M (2018-10-30)
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