SIRT1 deacetylates FOXO1

Stable Identifier
R-HSA-9626962
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SIRT1 deacetylates FOXO1
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A histone deacetylase SIRT1 deacetylates FOXO1. Deacetylation increases FOXO1-mediated upregulation of SOD2 and CDKN1B (Diatoku et al. 2004). SIRT-dependent deacetylation leads to retention of FOXO1 in the nucleus (Frescas et al. 2005).

Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein lysine deacetylase activity of SIRT1 [nucleoplasm]

Physical Entity
SIRT1 [nucleoplasm] (Homo sapiens)
Activity
protein lysine deacetylase activity (GO:0033558)
Inferred From
Sirt1 deacetylates Foxo1 (Mus musculus)
Authored
Orlic-Milacic, M  (2018-10-31)
Reviewed
Bertaggia, E  (2018-10-26)
Created
Orlic-Milacic, M  (2018-10-30)
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