Reactome | LRRC7 [cytosol]

LRRC7 [cytosol]

Stable Identifier

R-HSA-9611351

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Leucine-rich repeat-containing protein 7, LRRC7_HUMAN, Densin-180

Locations in the PathwayBrowser for interactor UniProt:P13569 CFTR

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External Reference Information

External Reference

UniProt:Q96NW7 LRRC7

Gene Names

LRRC7, KIAA1365, LAP1

Chain

chain:1-1537

Reference Genes

COSMIC - genes:LRRC7 LRRC7

ENSEMBL:ENSG00000033122 LRRC7

HGNC:18531 LRRC7

OMIM:614453 LRRC7

UCSC:Q96NW7 LRRC7

Participates

as a component of

as an input of

CaMKII and LRRC7 bind to NMDA receptors at postsynaptic density (Homo sapiens)

Other forms of this molecule

LRRC7 [extracellular region]

LRRC7 [specific granule lumen]

Inferred To

scrib [cytosol] (Drosophila melanogaster)

Lrrc7 [cytosol] (Mus musculus)

Lrrc7 [cytosol] (Rattus norvegicus)

LRRC7 [cytosol] (Bos taurus)

LRRC7 [cytosol] (Canis familiaris)

LRRC7 [cytosol] (Gallus gallus)

LRRC7 [cytosol] (Sus scrofa)

Ghost homologue of LRRC7 [cytosol] (Caenorhabditis elegans)

Ghost homologue of LRRC7 [cytosol] (Danio rerio)

Ghost homologue of LRRC7 [cytosol] (Xenopus tropicalis)

Cross References

OpenTargets

ENSG00000033122

GeneCards

LRRC7

PRO

Q96NW7

Pharos - Targets

Q96NW7

GlyGen

Q96NW7

PDB

6X5G, 7QQM

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UQB3 CTND2			0.609	2
UniProt:K9N5R3 VEMP			0.609	2
UniProt:Q99569 PKP4	2	PKP4 [cornified envelope] (R-HSA-8847721) PKP4 [plasma membrane] (R-HSA-6814401)	0.609	2
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.592	2
UniProt:Q8WXI2 CNKSR2	1	CNKSR2 [cytosol] (R-HSA-5672632)	0.592	2
UniProt:Q15303 ERBB4			0.592	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.571	2
UniProt:Q9Z1T4	1	Cnksr2 [cytosol] (R-RNO-5672632)	0.508	2
UniProt:O14656 TOR1A	1	TOR1A [cytosol] (R-HSA-8862858)	0.488	2
UniProt:Q9Y566 SHANK1	1	SHANK1 [cytosol] (R-HSA-6794274)	0.488	2

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