Reactome | Lrrc7 [cytosol]

Lrrc7 [cytosol]

Stable Identifier

R-RNO-9611351

Type

Protein [EntityWithAccessionedSequence]

Species

Rattus norvegicus

Compartment

cytosol

Synonyms

LRRC7, P70587

Locations in the PathwayBrowser

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Neuronal System (Rattus norvegicus)

- Transmission across Chemical Synapses (Rattus norvegicus)
  - Neurotransmitter receptors and postsynaptic signal transmission (Rattus norvegicus)
    - Activation of NMDA receptors and postsynaptic events (Rattus norvegicus)
      - Unblocking of NMDA receptors, glutamate binding and activation (Rattus norvegicus)
        
        Ca2+ influx into the post-synaptic cell (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2 NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2 NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        Lrrc7 [cytosol] (Rattus norvegicus)
        
        Membrane depolarization upon activation of Ca impermeable AMPA receptors (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors:p-T286-CaMKII dodecamer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        Lrrc7 [cytosol] (Rattus norvegicus)

Signal Transduction (Rattus norvegicus)

- MAPK family signaling cascades (Rattus norvegicus)
  - MAPK1/MAPK3 signaling (Rattus norvegicus)
    - RAF/MAP kinase cascade (Rattus norvegicus)
      - RAS GEFs promote RAS nucleotide exchange (Rattus norvegicus)
        
        RAS GEFs [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptor:RASGRF1 oligomer:CALM1:4xCa2+ [plasma membrane] (Rattus norvegicus)
        
        Gly,D-Ser:L-Glu:GRIN1:GRIN2B NMDA receptors [plasma membrane] (Rattus norvegicus)
        
        GRIN1:GRIN2B NMDA receptors:PSD proteins [plasma membrane] (Rattus norvegicus)
        
        Lrrc7 [cytosol] (Rattus norvegicus)

External Reference Information

External Reference

UniProt:P70587 Lrrc7

Gene Names

Lrrc7, Lap1

Chain

chain:1-1490

Reference Genes

BioGPS Gene:117284 Lrrc7

KEGG:rno:117284 Lrrc7

Monarch:117284 Lrrc7

NCBI Gene:117284 Lrrc7

UCSC:P70587 Lrrc7

Reference Transcript

RefSeq:NM_057142.1 Lrrc7

Other Identifiers

10827547

117284

1387320_a_at

17752220

5679432

5679904

5739823

5771044

5774108

5830301

5844910

5878795

5890671

5920102

5921905

5928195

5941057

5977691

6020738

6031073

6031658

6043959

6057809

6091506

6126251

6131279

6136182

6181451

6282995

6292910

6339329

6379230

6434647

6457541

6524189

6545011

6551411

6605938

6651878

6665541

6711277

A_42_P811021

A_64_P031304

A_64_P089105

GE20999

GO:0005515

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005912

GO:0007163

GO:0010976

GO:0014069

GO:0015629

GO:0016323

GO:0019901

GO:0030175

GO:0043113

GO:0043194

GO:0043197

GO:0043226

GO:0045197

GO:0045202

GO:0045211

GO:0098609

GO:0098839

GO:0098887

GO:0098978

GO:1901424

ILMN_1363787

U66707_at

Participates

as a component of

Other forms of this molecule

Lrrc7 [extracellular region]

Lrrc7 [specific granule lumen]

Lrrc7 [cytosol]

Inferred From

LRRC7 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_476483.1

ENSEMBL

ENSRNOT00000116114, ENSRNOP00000093706, ENSRNOG00000011980

PRO

P70587

RGD

708527

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31016 Dlg4	3	Dlg4 [plasma membrane] (R-RNO-9612601) Dlg4 [cytosol] (R-RNO-6794248) Dlg4 [endocytic vesicle membrane] (R-RNO-416847)	0.556	5
UniProt:P11798 Camk2a	6	phospho-p-T286-CAMK2A [plasma membrane] (R-MMU-432796) p-T286-Camk2a [nucleoplasm] (R-MMU-9608160) phospho-p-T286-CAMK2A [endocytic vesicle membrane] (R-MMU-416999) phospho-p-T286,T305,T306-CAMK2A [cytosol] (R-MMU-4332334) CAMK2A [cytosol] (R-MMU-4332329) phospho-p-T286-CAMK2A [cytosol] (R-MMU-445368)	0.544	2