Reactome | Recruitment of elongation factors to form elongation complex

Recruitment of elongation factors to form elongation complex

Stable Identifier

R-HSA-112379

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Recruitment of elongation factors to form elongation complex

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At the beginning of this reaction, 1 molecule of 'FACT complex', 1 molecule of 'Elongin Complex', 1 molecule of 'Early elongation complex with hyperphosphorylated Pol II CTD', 1 molecule of 'TFIIH', 1 molecule of 'RNA polymerase II elongation factor ELL', and 1 molecule of 'TFIIS protein' are present. At the end of this reaction, 1 molecule of 'Elongation complex' is present.

This reaction takes place in the 'nucleus'.

Literature References

PubMed ID	Title	Journal	Year
17234882	The Spt6 SH2 domain binds Ser2-P RNAPII to direct Iws1-dependent mRNA splicing and export Pickle, L, Jones, KA, Yoh, SM, Evans, RM, Cho, H	Genes Dev.	2007
19952111	DSIF, the Paf1 complex, and Tat-SF1 have nonredundant, cooperative roles in RNA polymerase II elongation Yamada, T, Yamaguchi, Y, Handa, H, Hisatake, K, Nakamura, M, Chen, Y, Tsugeno, Y, Yamamoto, J	Genes Dev.	2009
26659056	RNA polymerase II-associated factor 1 regulates the release and phosphorylation of paused RNA polymerase II Tang, Z, Yu, M, Roeder, RG, Zhu, J, Ni, T, Nakadai, T, Yang, W	Science	2015
12676794	The RNA polymerase II elongation complex. Conaway, JW, Shilatifard, A, Conaway, RC	Annu Rev Biochem	2003