Reactome | TIGAR [cytosol]

TIGAR [cytosol]

Stable Identifier

R-HSA-5628829

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Fructose-2,6-bisphosphatase TIGAR, C12orf5, TP53-induced glycolysis and apoptosis regulator

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9NQ88 TIGAR

Gene Names

TIGAR, C12orf5

Chain

chain:1-270

Reference Genes

BioGPS Gene:57103 TIGAR

COSMIC (genes):TIGAR TIGAR

CTD Gene:57103 TIGAR

dbSNP Gene:57103 TIGAR

ENSEMBL:ENSG00000078237 TIGAR

HGNC:1185 TIGAR

KEGG:hsa:57103 TIGAR

Monarch:57103 TIGAR

NCBI Gene:57103 TIGAR

OMIM:610775 TIGAR

UCSC:Q9NQ88 TIGAR

Reference Transcript

RefSeq:NM_020375.2 TIGAR

Other Identifiers

11719731_at

11719732_at

16747004

219099_PM_at

219099_at

2515239

3401743

3401745

3401746

3401747

3401749

3401751

3401757

3401758

3401759

3401762

3401764

3401765

3401768

3401770

3401771

3401772

3401773

3401774

3401775

3401776

3401777

3401778

3401779

3401780

3401782

3401783

3401785

3401787

3401788

50396_at

57103

7953211

A_23_P128486

A_24_P564462

A_33_P3258452

GE576725

GE61956

GE867496

GO:0000423

GO:0002931

GO:0003824

GO:0004331

GO:0005515

GO:0005634

GO:0005737

GO:0005739

GO:0005741

GO:0005829

GO:0005975

GO:0006003

GO:0006091

GO:0006096

GO:0006914

GO:0006915

GO:0006974

GO:0007005

GO:0009410

GO:0010332

GO:0010659

GO:0010666

GO:0012501

GO:0016787

GO:0019661

GO:0043069

GO:0043226

GO:0043456

GO:0045739

GO:0045820

GO:0048856

GO:0055086

GO:0060576

GO:0071279

GO:0071456

GO:0072593

GO:1901135

GO:1901525

GO:1902153

GO:1903301

GO:1904024

GO:1905857

GO:2000378

HMNXSV003006464

ILMN_1791792

PH_hs_0002180

TC12000061.hg

g9966848_3p_at

Participates

as an output of

TP53 stimulates TIGAR expression (Homo sapiens)

Inferred To

TIGAR [cytosol] (Bos taurus)

TIGAR [cytosol] (Canis familiaris)

TIGAR [cytosol] (Gallus gallus)

TIGAR [cytosol] (Rattus norvegicus)

TIGAR [cytosol] (Sus scrofa)

tigar [cytosol] (Xenopus tropicalis)

Tigar [cytosol] (Mus musculus)

tigara [cytosol] (Danio rerio)

Cross References

RefSeq

NP_065108.1

ENSEMBL

ENSP00000179259, ENST00000179259

OpenTargets

ENSG00000078237

HPA

ENSG00000078237-TIGAR

PRO

Q9NQ88

Pharos - Targets

Q9NQ88

GlyGen

Q9NQ88

HMDB Protein

HMDBP11978

PDB

3DCY

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y371 SHLB1			0.556	3
UniProt:P55212 CASP6	5	CASP6(194-293) [cytosol] (R-HSA-266128) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6 (1-293) [cytosol] (R-HSA-6798132)	0.556	3
UniProt:P13473-2 P134732			0.556	3
UniProt:O00291 HIP1	7	HIP1(1-719)insL-ALK(1059-1620) fusion [cytosol] (R-HSA-9711952) HIP1(1-1019)-ALK(1058-1620) [cytosol] (R-HSA-9711970) HIP1(1-963)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711972) HIP1(1-719)insL-p-7Y-ALK(1059-1620) fusion [cytosol] (R-HSA-9711965) HIP1(1-1019)-p-7Y-ALK(1058-1620) [cytosol] (R-HSA-9711956) HIP1(1-963)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711975) HIP1 [cytosol] (R-HSA-8868153)	0.556	3
UniProt:P41247 PNPLA4	1	PNPLA4 [cytosol] (R-HSA-8848356)	0.527	2
UniProt:P52789 HK2	1	HK2 [cytosol] (R-HSA-70378)	0.524	3

© 2025 Reactome

Cite Us!