Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
SMG6
Stable Identifier
R-HSA-927851
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Telomerase-binding protein EST1A, EST1A_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Nonsense-Mediated Decay (NMD) (Homo sapiens)
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Homo sapiens)
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex (Homo sapiens)
SMG6 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
SMG6 [cytosol] (Homo sapiens)
SMG6 hydrolyzes mRNA with premature termination codon (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
SMG6 [cytosol] (Homo sapiens)
SMG6 [cytosol] (Homo sapiens)
mRNA Cleaved by SMG6 [cytosol] (Homo sapiens)
SMG6 [cytosol] (Homo sapiens)
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Homo sapiens)
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Homo sapiens)
SMG6 [cytosol] (Homo sapiens)
SMG6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q86US8 SMG6
Gene Names
SMG6, C17orf31, EST1A, KIAA0732
Chain
chain:1-1419
Reference Genes
BioGPS Gene:23293 SMG6
COSMIC (genes):SMG6 SMG6
CTD Gene:23293 SMG6
dbSNP Gene:23293 SMG6
ENSEMBL:ENSG00000070366 SMG6
HGNC:17809 SMG6
KEGG Gene (Homo sapiens):hsa:23293 SMG6
Monarch:23293 SMG6
NCBI Gene:23293 SMG6
OMIM:610963 SMG6
UCSC:Q86US8 SMG6
Reference Transcript
RefSeq:NM_001256827.1 SMG6
RefSeq:NM_001282326.1 SMG6
RefSeq:XM_011523769.2 SMG6
RefSeq:NM_017575.4 SMG6
RefSeq:XM_005256569.3 SMG6
RefSeq:NM_001256828.1 SMG6
RefSeq:XM_011523775.2 SMG6
RefSeq:XM_005256571.4 SMG6
RefSeq:XM_017024399.1 SMG6
Other Identifiers
0002230170
11720869_a_at
11745314_a_at
16839554
214940_s_at
23293
2DOK
2HWW
2HWX
33798_at
3740839
3740840
3740841
3740842
3740849
3740853
3740855
3740865
3740869
3740870
3740901
3740906
3740907
3740924
3740925
3740932
3740936
3740941
3740942
3740943
3740944
3740945
3740946
3740948
3740949
3740954
3740955
42932
4UM2
8011222
A_23_P100676
CCDS11016
CCDS58498
ENSG00000070366
ENSP00000263073
ENSP00000346977
ENSP00000440283
ENST00000263073
ENST00000354901
ENST00000536871
EntrezGene:23293
GE56630
GO:0000184
GO:0000333
GO:0000781
GO:0003677
GO:0003723
GO:0004518
GO:0004519
GO:0004521
GO:0005515
GO:0005634
GO:0005694
GO:0005697
GO:0005730
GO:0005737
GO:0005829
GO:0006406
GO:0016787
GO:0032204
GO:0032210
GO:0035145
GO:0035303
GO:0042162
GO:0043021
GO:0043487
GO:0046872
GO:0051972
GO:0070034
GO:0070182
GO:0090305
GO:0090502
GO:1904354
HGNC:17809
HPA042932
Hs.20185.1.S1_3p_a_at
Hs.448342
ILMN_1695280
ILMN_1701379
MIM:610963
NM_001256827
NM_001256828
NM_017575
NP_001243756
NP_001243757
NP_060045
PF10373
PF10374
PF13638
PH_hs_0026197
SM00670
SMG6
SMG6-201
SMG6-202
SMG6-203
TC17000988.hg
uc002fub.2
uc010vqv.2
uc031qxx.2
UPI00002005C8
UPI00002005CB
XM_005256569
XM_005256571
XM_011523769
XM_011523775
XM_017024399
XP_005256626
XP_005256628
XP_011522071
XP_011522077
XP_016879888
Participant Of
input
p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A
hasComponent
mRNA Cleaved by SMG6 [cytosol]
Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol]
output
Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
Inferred To
SMG6 [cytosol] (Arabidopsis thaliana)
SMG6 [cytosol] (Bos taurus)
SMG6 [cytosol] (Canis familiaris)
SMG6 [cytosol] (Danio rerio)
SMG6 [cytosol] (Drosophila melanogaster)
SMG6 [cytosol] (Gallus gallus)
SMG6 [cytosol] (Mus musculus)
SMG6 [cytosol] (Oryza sativa)
SMG6 [cytosol] (Rattus norvegicus)
SMG6 [cytosol] (Sus scrofa)
SMG6 [cytosol] (Taeniopygia guttata)
SMG6 [cytosol] (Xenopus tropicalis)
Ghost homologue of SMG6 [cytosol] (Caenorhabditis elegans)
Ghost homologue of SMG6 [cytosol] (Dictyostelium discoideum)
Ghost homologue of SMG6 [cytosol] (Plasmodium falciparum)
Ghost homologue of SMG6 [cytosol] (Saccharomyces cerevisiae)
Ghost homologue of SMG6 [cytosol] (Schizosaccharomyces pombe)
Homologues of SMG6 [cytosol] (Arabidopsis thaliana)
Homologues of SMG6 [cytosol] (Drosophila melanogaster)
Homologues of SMG6 [cytosol] (Gallus gallus)
Homologues of SMG6 [cytosol] (Oryza sativa)
Homologues of SMG6 [cytosol] (Rattus norvegicus)
Cross References
RefSeq
NP_001243756.1
,
XP_005256628.1
,
NP_001243757.1
,
XP_011522071.1
,
NP_001269255.1
,
XP_011522077.1
,
XP_016879888.1
,
NP_060045.4
,
XP_005256626.1
Brenda
3.1
GeneCards
Q86US8
DOCK Blaster
2HWW
,
2HWX
,
4UM2
,
2DOK
PRO
Q86US8
PDB
2DOK
,
2HWW
,
2HWX
,
4UM2
HMDB Protein
HMDBP08841
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92900-2 UPF1
0.499
2
UniProt:P50222 MEOX2
0.488
2
UniProt:Q9Q2G4 Q9Q2G4
0.462
2
© 2018
Reactome