Reactome | FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

Stable Identifier

R-HSA-8854050

DOI

10.3180/R-HSA-8854050.1

Type

Pathway

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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FBXL7 down-regulates AURKA during mitotic entry and in early mitosis

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The protein levels of aurora kinase A (AURKA) during mitotic entry and in early mitosis can be reduced by the action of the SCF-FBXL7 E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXL7 subunits. FBXL7 is the substrate recognition subunit of the SCF-FBXL7 complex that associates with the centrosome-bound AURKA, promoting its ubiquitination and proteasome-mediated degradation. Overexpression of FBXL7 results in G2/M cell cycle arrest and apoptosis (Coon et al. 2011).

FBXL7 protein levels are down-regulated by the action of the SCF-FBXL18 E3 ubiquitin ligase complex, consisting of SKP1, CUL1, RBX1 and the substrate recognition subunit FBXL18. FBXL18 binds to the FQ motif of FBXL7, targeting it for ubiquitination and proteasome-mediated degradation, counteracting its pro-apoptotic activity (Liu et al. 2015). Cell cycle stage-dependency of down-regulation of FBXL7 by FBXL18 is unknown.

Literature References

PubMed ID	Title	Journal	Year
25654763	F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7 Zou, C, Liu, Y, Chen, BB, Lear, T, Mallampalli, RK, Zhao, Y, Zhao, J	Cell Death Dis	2015
22306998	Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest Glasser, JR, Chen, BB, Coon, TA, Mallampalli, RK	Cell Cycle	2012