Reactome | G2/M Transition

G2/M Transition

Stable Identifier

R-HSA-69275

DOI

10.3180/REACT_2203.2

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Together with two B-type cyclins, CCNB1 and CCNB2, Cdc2 (CDK1) regulates the transition from G2 into mitosis. CDK1 can also form complexes with Cyclin A (CCNA1 and CCNA3). CDK1 complexes with A and B type cyclins are activated by dephosphorylation of CDK1 threonine residue T14 and tyrosine residue Y15. Cyclin A:CDK1 and Cyclin B:CDK1 complexes phosphorylate several proteins involved in mitotic spindle formation and function, the breakdown of the nuclear envelope, and chromosome condensation that is necessary for the ~2 meters of DNA to be segregated at mitosis (Nigg 1998, Nilsson and Hoffmann 2000, Salaun et al. 2008, Fisher et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23223895	Phosphorylation network dynamics in the control of cell cycle transitions Fisher, D, Krasinska, L, Coudreuse, D, Novák, B	J. Cell. Sci.	2012
10740819	Cell cycle regulation by the Cdc25 phosphatase family Nilsson, I, Hoffmann, I	Prog Cell Cycle Res	2000
18497029	Cdk1, Plks, Auroras, and Neks: the mitotic bodyguards Salaun, P, Rannou, Y, Prigent, C	Adv. Exp. Med. Biol.	2008
9914175	Polo-like kinases: positive regulators of cell division from start to finish Nigg, EA	Curr. Opin. Cell Biol.	1998