SCF-FBXL7 ubiquitinates AURKA

Stable Identifier
R-HSA-8854041
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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SCF-FBXL7 ubiquitinates AURKA
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The SCF-FBXL7 E3 ubiquitin ligase complex, composed of SKP1, CUL1, RBX1 and FBXL7, ubiquitinates aurora kinase A (AURKA), targeting it for degradation (Coon et al. 2012).

Literature References
PubMed ID Title Journal Year
22306998 Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

Glasser, JR, Chen, BB, Coon, TA, Mallampalli, RK

Cell Cycle 2012
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of G2/M transition of mitotic cell cycle (0010972)
Catalyst Activity

ubiquitin protein ligase activity of SCF-FBXL7:AURKA [cytosol]

Physical Entity
SCF-FBXL7:AURKA [cytosol] (Homo sapiens)
Activity
ubiquitin protein ligase activity (GO:0061630)
Orthologous Events
SCF-FBXL7 ubiquitinates AURKA (Bos taurus)
SCF-FBXL7 ubiquitinates AURKA (Caenorhabditis elegans)
SCF-FBXL7 ubiquitinates AURKA (Canis familiaris)
SCF-FBXL7 ubiquitinates AURKA (Danio rerio)
SCF-FBXL7 ubiquitinates AURKA (Dictyostelium discoideum)
SCF-FBXL7 ubiquitinates AURKA (Drosophila melanogaster)
SCF-FBXL7 ubiquitinates AURKA (Gallus gallus)
SCF-FBXL7 ubiquitinates AURKA (Mus musculus)
SCF-FBXL7 ubiquitinates AURKA (Rattus norvegicus)
SCF-FBXL7 ubiquitinates AURKA (Sus scrofa)
SCF-FBXL7 ubiquitinates AURKA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-27)
Reviewed
Lindon, C  (2016-05-13)
Grant, R  (2016-05-13)
Created
Orlic-Milacic, M  (2016-01-27)
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