SCF-FBXL7 ubiquitinates AURKA

Stable Identifier
R-HSA-8854041
Type
Reaction
Species
Homo sapiens
Compartment
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The SCF-FBXL7 E3 ubiquitin ligase complex, composed of SKP1, CUL1, RBX1 and FBXL7, ubiquitinates aurora kinase A (AURKA), targeting it for degradation (Coon et al. 2012).

Literature References
PubMed ID Title Journal Year
22306998 Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

Glasser, JR, Chen, BB, Coon, TA, Mallampalli, RK

Cell Cycle 2012
Participants
Participates
Event Information
Catalyst Activity

ubiquitin protein ligase activity of SCF-FBXL7:AURKA [cytosol]

Orthologous Events
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