Proteasome-mediated degradation of PolyUb-FBXL7

Stable Identifier
R-HSA-8854071
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Proteasome-mediated degradation of PolyUb-FBXL7
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FBXL7, polyubiquitinated by the FBXL18-containing SCF complex, is degraded by the proteasome (Liu et al. 2015).
Literature References
PubMed ID Title Journal Year
25654763 F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7

Liu, Y, Lear, T, Zhao, Y, Zhao, J, Zou, C, Chen, BB, Mallampalli, RK

Cell Death Dis 2015
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Input
Output
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as an event of
Event Information
Go Biological Process
SCF-dependent proteasomal ubiquitin-dependent protein catabolic process (0031146)
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasome-mediated degradation of PolyUb-FBXL7 (Bos taurus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Caenorhabditis elegans)
Proteasome-mediated degradation of PolyUb-FBXL7 (Canis familiaris)
Proteasome-mediated degradation of PolyUb-FBXL7 (Danio rerio)
Proteasome-mediated degradation of PolyUb-FBXL7 (Dictyostelium discoideum)
Proteasome-mediated degradation of PolyUb-FBXL7 (Drosophila melanogaster)
Proteasome-mediated degradation of PolyUb-FBXL7 (Gallus gallus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Mus musculus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Rattus norvegicus)
Proteasome-mediated degradation of PolyUb-FBXL7 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-01-27)
Reviewed
Grant, R  (2016-05-13)
Lindon, C  (2016-05-13)
Created
Orlic-Milacic, M  (2016-01-27)
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