SCF:FBXL7 binds AURKA

Stable Identifier
R-HSA-8853496
Type
Reaction
Species
Homo sapiens
Compartment
cytosol
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SCF:FBXL7 binds AURKA
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FBXL7, a component of the SCF E3 ubiquitin ligase complex, associates with aurora kinase A (AURKA) during mitosis (Coon et al. 2012).

Literature References
PubMed ID Title Journal Year
22306998 Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

Glasser, JR, Chen, BB, Coon, TA, Mallampalli, RK

Cell Cycle 2012
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of G2/M transition of mitotic cell cycle (0010972)
Orthologous Events
SCF:FBXL7 binds AURKA (Bos taurus)
SCF:FBXL7 binds AURKA (Caenorhabditis elegans)
SCF:FBXL7 binds AURKA (Canis familiaris)
SCF:FBXL7 binds AURKA (Danio rerio)
SCF:FBXL7 binds AURKA (Dictyostelium discoideum)
SCF:FBXL7 binds AURKA (Drosophila melanogaster)
SCF:FBXL7 binds AURKA (Gallus gallus)
SCF:FBXL7 binds AURKA (Mus musculus)
SCF:FBXL7 binds AURKA (Rattus norvegicus)
SCF:FBXL7 binds AURKA (Saccharomyces cerevisiae)
SCF:FBXL7 binds AURKA (Schizosaccharomyces pombe)
SCF:FBXL7 binds AURKA (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-01-26)
Reviewed
Lindon, C  (2016-05-13)
Grant, R  (2016-05-13)
Created
Orlic-Milacic, M  (2016-01-22)
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