SCF:FBXL7 binds AURKA

Stable Identifier
R-HSA-8853496
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
SCF:FBXL7 binds AURKA
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

FBXL7, a component of the SCF E3 ubiquitin ligase complex, associates with aurora kinase A (AURKA) during mitosis (Coon et al. 2012).

Literature References
PubMed ID Title Journal Year
22306998 Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

Glasser, JR, Chen, BB, Coon, TA, Mallampalli, RK

Cell Cycle 2012
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of G2/M transition of mitotic cell cycle (0010972)
Orthologous Events
SCF:FBXL7 binds AURKA (Bos taurus)
SCF:FBXL7 binds AURKA (Caenorhabditis elegans)
SCF:FBXL7 binds AURKA (Canis familiaris)
SCF:FBXL7 binds AURKA (Danio rerio)
SCF:FBXL7 binds AURKA (Dictyostelium discoideum)
SCF:FBXL7 binds AURKA (Drosophila melanogaster)
SCF:FBXL7 binds AURKA (Gallus gallus)
SCF:FBXL7 binds AURKA (Mus musculus)
SCF:FBXL7 binds AURKA (Rattus norvegicus)
SCF:FBXL7 binds AURKA (Saccharomyces cerevisiae)
SCF:FBXL7 binds AURKA (Sus scrofa)
SCF:FBXL7 binds AURKA (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-27)
Reviewed
Lindon, C  (2016-05-13)
Grant, R  (2016-05-13)
Created
Orlic-Milacic, M  (2016-01-23)
Cite Us!