Proteasome degrades AURKA ubiquitinated by SCF-FBXL7

Stable Identifier
R-HSA-8854044
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Upon ubiquitination by the SCF-FBXL7 E3 ubiquitin ligase complex, aurora kinase A (AURKA) is degraded by the proteasome (Coon et al. 2012).
Literature References
PubMed ID Title Journal Year
22306998 Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

Coon, TA, Glasser, JR, Mallampalli, RK, Chen, BB

Cell Cycle 2012
Participants
Input
Output
Participates
as an event of
Event Information
Go Biological Process
negative regulation of G2/M transition of mitotic cell cycle (0010972)
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Dictyostelium discoideum)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Gallus gallus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Plasmodium falciparum)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Rattus norvegicus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Saccharomyces cerevisiae)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Schizosaccharomyces pombe)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Xenopus tropicalis)
Authored
Orlic-Milacic, M  (2016-01-27)
Reviewed
Grant, R  (2016-05-13)
Lindon, C  (2016-05-13)
Created
Orlic-Milacic, M  (2016-01-27)
Cite Us!