Proteasome degrades AURKA ubiquitinated by SCF-FBXL7

Stable Identifier
R-HSA-8854044
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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Proteasome degrades AURKA ubiquitinated by SCF-FBXL7
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Upon ubiquitination by the SCF-FBXL7 E3 ubiquitin ligase complex, aurora kinase A (AURKA) is degraded by the proteasome (Coon et al. 2012).

Literature References
PubMed ID Title Journal Year
22306998 Novel E3 ligase component FBXL7 ubiquitinates and degrades Aurora A, causing mitotic arrest

Glasser, JR, Chen, BB, Coon, TA, Mallampalli, RK

Cell Cycle 2012
Participants
Input
Output
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as an event of
Event Information
Go Biological Process
negative regulation of G2/M transition of mitotic cell cycle (0010972)
Catalyst Activity

endopeptidase activity of 26S proteasome [cytosol]

Physical Entity
26S proteasome [cytosol] (Homo sapiens)
Activity
endopeptidase activity (GO:0004175)
Orthologous Events
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Bos taurus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Caenorhabditis elegans)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Canis familiaris)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Danio rerio)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Dictyostelium discoideum)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Drosophila melanogaster)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Mus musculus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Rattus norvegicus)
Proteasome degrades AURKA ubiquitinated by SCF-FBXL7 (Sus scrofa)
Authored
Orlic-Milacic, M  (2016-01-27)
Reviewed
Lindon, C  (2016-05-13)
Grant, R  (2016-05-13)
Created
Orlic-Milacic, M  (2016-01-27)
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