Reactome | CEP97 [cytosol]

CEP97 [cytosol]

Stable Identifier

R-HSA-5626440

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - CEP97 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
  - Signaling by Rho GTPases (Homo sapiens)
    - RHO GTPase cycle (Homo sapiens)
      - RHOV GTPase cycle (Homo sapiens)
        
        RHOV binds effectors at the plasma membrane (Homo sapiens)
        
        RHOV effectors [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)
        
        RHOV:GTP:RHOV effectors [plasma membrane] (Homo sapiens)
        
        RHOV effectors [cytosol] (Homo sapiens)
        
        CEP97 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
17719545	Cep97 and CP110 suppress a cilia assembly program Dynlacht, BD, Spektor, A, Khoo, D, Tsang, WY	Cell	2007

External Reference Information

External Reference

UniProt:Q8IW35 CEP97

Gene Names

CEP97, LRRIQ2

Chain

chain:1-865

Reference Genes

BioGPS Gene:79598 CEP97

COSMIC (genes):CEP97 CEP97

CTD Gene:79598 CEP97

dbSNP Gene:79598 CEP97

ENSEMBL:ENSG00000182504 CEP97

HGNC:26244 CEP97

Monarch:79598 CEP97

NCBI Gene:79598 CEP97

OMIM:615864 CEP97

UCSC:Q8IW35 CEP97

Reference Transcript

Other Identifiers

11730572_at

11752133_a_at

16943435

219886_PM_at

219886_at

235918_3p_x_at

235918_PM_x_at

235918_x_at

241836_3p_x_at

241836_PM_x_at

241836_x_at

2634032

2634033

2634034

2634035

2634036

2634037

2634039

2634040

2634041

2634044

2634045

2634046

2634047

2634048

2634049

2634050

2634052

2634053

2634054

2634055

2634056

2634057

2993694

58022_at

63456_r_at

7894787

79598

8081362

81846_r_at

A_14_P121420

A_23_P143952

A_24_P418294

A_24_P920355

GE82857

GO:0005515

GO:0005516

GO:0005737

GO:0005813

GO:0005814

GO:0005815

GO:0005829

GO:0005856

GO:0030030

GO:0032991

GO:0043226

GO:1901673

GO:1902018

HMNXSV003008992

HMNXSV003010309

Hs.125273.0.S1_3p_at

Hs.125273.0.S1_3p_x_at

Hs.293691.0.A1_3p_x_at

ILMN_1736951

PH_hs_0041174

TC03000524.hg

g13375710_3p_at

Participates

as a candidate of

RHOV effectors [cytosol] (Homo sapiens)

as an output of

CP110 and CEP97 dissociate from the centriole (Homo sapiens)

as a component of

mother centriole [cytosol] (Homo sapiens)

Inferred To

CT33170 [cytosol] (Drosophila melanogaster)

Homologues of CEP97 [cytosol] (Drosophila melanogaster)

CEP97 [cytosol] (Bos taurus)

CEP97 [cytosol] (Canis familiaris)

Ghost homologue of CEP97 [cytosol] (Gallus gallus)

Ghost homologue of CEP97 [cytosol] (Sus scrofa)

Cep97 [cytosol] (Drosophila melanogaster)

Cep97 [cytosol] (Mus musculus)

Cep97 [cytosol] (Rattus norvegicus)

dtr [cytosol] (Drosophila melanogaster)

cep97 [cytosol] (Xenopus tropicalis)

Cross References

ENSEMBL

ENSP00000342510, ENST00000341893, ENST00000704365, ENSP00000515873

OpenTargets

ENSG00000182504

HPA

ENSG00000182504-CEP97

PRO

Q8IW35

Pharos - Targets

Q8IW35

GlyGen

Q8IW35

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43303 CCP110	2	CCP110 [cytosol] (R-HSA-380261) PolyUb-CCP110 [cytosol] (R-HSA-6783044)	0.953	31
UniProt:Q5T7B8 KIF24	1	KIF24 [cytosol] (R-HSA-5626651)	0.81	14
UniProt:P62158 CALM			0.779	5
UniProt:O15078 CEP290	3	CEP290 [extracellular region] (R-HSA-6806291) CEP290 [specific granule lumen] (R-HSA-6799524) CEP290 [cytosol] (R-HSA-380275)	0.745	10
UniProt:Q8TAP6 CEP76	1	CEP76 [cytosol] (R-HSA-380281)	0.643	6
UniProt:Q9Y2Z0 SUGT1	1	SUGT1 [cytosol] (R-HSA-874107)	0.615	3
UniProt:Q8NHV4 NEDD1	1	NEDD1 [cytosol] (R-HSA-379267)	0.615	3
UniProt:Q562R1 ACTBL			0.611	3
UniProt:P53350 PLK1	4	PLK1 [cytosol] (R-HSA-164603) p-T210-PLK1 [nucleoplasm] (R-HSA-3002800) p-T210-PLK1 [cytosol] (R-HSA-3000318) PLK1 [nucleoplasm] (R-HSA-156720)	0.527	2
UniProt:Q15154 PCM1	1	PCM1 [cytosol] (R-HSA-380308)	0.483	2
UniProt:Q9BVV6 TALD3			0.462	5