Reactome | PHLPP1 [cytosol]

PHLPP1 [cytosol]

Stable Identifier

R-HSA-199421

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

PH domain leucine-rich repeat-containing protein phosphatase, PHLPP_HUMAN, PHLPP

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Intracellular signaling by second messengers (Homo sapiens)
  - PIP3 activates AKT signaling (Homo sapiens)
    - Negative regulation of the PI3K/AKT network (Homo sapiens)
      - PHLPP dephosphorylates S473 in AKT (Homo sapiens)
        
        PHLPP (Mn2+ cofactor) [cytosol] (Homo sapiens)
        
        PHLPP [cytosol] (Homo sapiens)
        
        PHLPP1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60346 PHLPP1

Gene Names

PHLPP1, KIAA0606, PHLPP, PLEKHE1, SCOP

Chain

chain:1-1717

Reference Genes

BioGPS Gene:23239 PHLPP1

COSMIC (genes):PHLPP1 PHLPP1

CTD Gene:23239 PHLPP1

dbSNP Gene:23239 PHLPP1

ENSEMBL:ENSG00000081913 PHLPP1

ENSEMBL:ENSG00000081913.14 PHLPP1

HGNC:20610 PHLPP1

KEGG Gene (Homo sapiens):23239 PHLPP1

Monarch:23239 PHLPP1

NCBI Gene:23239 PHLPP1

OMIM:609396 PHLPP1

UCSC:O60346 PHLPP1

Reference Transcript

RefSeq:NM_194449.3 PHLPP1

Other Identifiers

11719250_s_at

11719251_at

16852789

212719_PM_at

212719_at

23239

35719_at

3791483

3791484

3791485

3791486

3791487

3791488

3791489

3791490

3791514

3791517

3791526

3791532

3791533

3791534

3791535

3791536

3791538

3791547

3791548

3791554

3791555

3791557

3791558

3791561

3791562

3791563

3791564

3791565

3791566

3791567

3791568

3791569

3791570

3791571

3791572

3791615

3791617

3791619

3791621

3791623

3791625

8021565

A_14_P114790

GE53306

GO:0002376

GO:0002667

GO:0003824

GO:0004721

GO:0004722

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006915

GO:0009649

GO:0012501

GO:0016020

GO:0016787

GO:0017018

GO:0023052

GO:0042981

GO:0043226

GO:0043231

GO:0043408

GO:0046328

GO:0046872

GO:0048856

GO:0051898

GO:0140096

GO:1900744

HMNXSV003006244

Hs.38176.0.S1_3p_at

ILMN_1814661

PH_hs_0028862

TC18000224.hg

Participates

as a member of

PHLPP [cytosol] (Homo sapiens)

Inferred To

phlp-2 [cytosol] (Caenorhabditis elegans)

Homologues of PHLPP1 [cytosol] (Drosophila melanogaster)

Phlpp [cytosol] (Drosophila melanogaster)

Lrr47 [cytosol] (Drosophila melanogaster)

PHLPP1 [cytosol] (Canis familiaris)

PHLPP1 [cytosol] (Danio rerio)

PHLPP1 [cytosol] (Gallus gallus)

PHLPP1 [cytosol] (Mus musculus)

PHLPP1 [cytosol] (Rattus norvegicus)

lrrA [cytosol] (Dictyostelium discoideum)

CT11751 [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_919431.2

OpenTargets

ENSG00000081913

IntEnz

3.1.3.16

GeneCards

O60346

HPA

ENSG00000081913-PHLPP1

ZINC - Substances

PHLP1_HUMAN

Ensembl

ENSG00000081913, ENSP00000262719, ENST00000262719

ZINC target

O60346

PRO

O60346

Pharos - Targets

O60346

ZINC - Predictions - Purchasable

PHLP1_HUMAN

HMDB Protein

HMDBP08850

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O94782 USP1	3	USP1 [nucleoplasm] (R-HSA-419546) USP1(672-785) [nucleoplasm] (R-HSA-5655474) USP1(1-671) [nucleoplasm] (R-HSA-5655484)	0.695	5
UniProt:Q9Y2Z0 SUGT1	1	SUGT1 [cytosol] (R-HSA-874107)	0.604	3
UniProt:Q8TAF3 WDR48	3	p-12Y-WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673645) WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol] (R-HSA-9673617) WDR48 [nucleoplasm] (R-HSA-419549)	0.604	4
UniProt:Q14160 SCRIB	1	SCRIB [cytosol] (R-HSA-4608858)	0.589	2
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.564	2