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GNA13 [plasma membrane]
Stable Identifier
R-HSA-167451
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
G protein alpha 13
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Signal amplification (Homo sapiens)
Thromboxane signalling through TP receptor (Homo sapiens)
Activated TP receptor binds G-protein G13 (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Dissociation of the TP:G13 complex (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
G13 activation by TP receptor (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
TP receptor:Thromboxane A2:G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Thrombin signalling through proteinase activated receptors (PARs) (Homo sapiens)
Thrombin-activated PARs activate G12/13 (Homo sapiens)
Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs binds G-protein G12/13 (Homo sapiens)
G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Thrombin activated PAR:G12/13 (inactive) [plasma membrane] (Homo sapiens)
G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Thrombin-activated PARs:G12/13 (active) dissociate (Homo sapiens)
G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Thrombin activated PAR:G12/13 (active) [plasma membrane] (Homo sapiens)
G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signaling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP (Homo sapiens)
G-protein alpha (12/13):GDP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
G alpha (13) activates Rho guanine nucleotide exchange factor 1 (p115-RhoGEF) (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Inactive G alpha (12/13) reassociates with G beta:gamma (Homo sapiens)
G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
G-protein alpha (12/13):GDP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
LARG activation by G alpha 12/13 (Homo sapiens)
G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
G-protein alpha (12/13):LARG [plasma membrane] (Homo sapiens)
G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
LARG binds plexin B1 (Homo sapiens)
G-protein alpha (12/13):LARG [plasma membrane] (Homo sapiens)
G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
G-protein alpha (12/13):LARG:Plexin B1 [plasma membrane] (Homo sapiens)
G-protein alpha (12/13):LARG [plasma membrane] (Homo sapiens)
G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Liganded G12/13-activating GPCR acts as a GEF for G12/13 (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Liganded G12/13-activating GPCRs bind inactive heterotrimeric G-protein G12/13 (Homo sapiens)
G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (inactive). [plasma membrane] (Homo sapiens)
G-protein G12/G13 (inactive) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (inactive) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:G12/13 complex dissociates (Homo sapiens)
G-protein alpha (12/13):GTP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate G12/13:Heterotrimeric G-protein G12/13 (active). [plasma membrane] (Homo sapiens)
G-protein G12/G13 (active) [plasma membrane] (Homo sapiens)
Heterotrimeric G-protein G13 (active) [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
p115-RhoGEF activation of RHOA (Homo sapiens)
G13-activated p115-RhoGEF [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
CDC42 GTPase cycle (Homo sapiens)
CDC42 GEFs activate CDC42 (Homo sapiens)
CDC42 GEFs [cytosol] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
GNA13 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14344 GNA13
Gene Names
GNA13
Chain
chain:1-377
Reference Genes
BioGPS Gene:10672 GNA13
COSMIC (genes):GNA13 GNA13
CTD Gene:10672 GNA13
dbSNP Gene:10672 GNA13
ENSEMBL:ENSG00000120063 GNA13
ENSEMBL_homo_sapiens_GENE:ENSG00000120063.10 GNA13
HGNC:4381 GNA13
KEGG Gene (Homo sapiens):10672 GNA13
Monarch:10672 GNA13
NCBI Gene:10672 GNA13
OMIM:604406 GNA13
UCSC:Q14344 GNA13
Reference Transcript
RefSeq:NM_001282425.1 GNA13
RefSeq:NM_006572.5 GNA13
Other Identifiers
10672
1139_at
11717681_at
11717682_a_at
11748689_a_at
11755222_a_at
16847921
206917_PM_at
206917_at
224761_PM_at
224761_at
227539_PM_at
227539_at
2674353
33635_at
3767340
3767341
3767342
3767343
3767344
3767345
3767347
3767355
3767358
3767359
3767360
3767361
47128_at
48764_at
58827_at
7893289
8017711
A_23_P78281
A_24_P150874
A_24_P941441
GE56024
GE80003
GO:0000166
GO:0001525
GO:0001569
GO:0001664
GO:0001701
GO:0003013
GO:0003824
GO:0003924
GO:0005085
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005834
GO:0005886
GO:0005925
GO:0007165
GO:0007186
GO:0007188
GO:0007189
GO:0007204
GO:0007266
GO:0008217
GO:0008360
GO:0010762
GO:0016020
GO:0016787
GO:0019001
GO:0023052
GO:0030154
GO:0030168
GO:0031410
GO:0031526
GO:0031683
GO:0031752
GO:0035556
GO:0042060
GO:0042470
GO:0043226
GO:0046872
GO:0048856
GO:0048870
GO:0051056
GO:0070062
GO:0098772
GO:1904706
GO:1904753
HMNXSV003031280
Hs.87518.0.A1_3p_at
Hs.9691.0.S1_3p_at
ILMN_1758906
ILMN_2176037
L22075_at
PH_hs_0001001
TC17001808.hg
g5729847_3p_at
Participates
as a candidate of
CDC42 GEFs [cytosol] (Homo sapiens)
as a member of
RAC1 GEFs [cytosol] (Homo sapiens)
as a component of
G-protein alpha (13):GDP [plasma membrane] (Homo sapiens)
G-protein alpha (13):GTP [plasma membrane] (Homo sapiens)
Inferred To
GNA13 [plasma membrane]
(Bos taurus)
GNA13 [plasma membrane]
(Caenorhabditis elegans)
GNA13 [plasma membrane]
(Canis familiaris)
GNA13 [plasma membrane]
(Dictyostelium discoideum)
GNA13 [plasma membrane]
(Drosophila melanogaster)
GNA13 [plasma membrane]
(Gallus gallus)
GNA13 [plasma membrane]
(Rattus norvegicus)
GNA13 [plasma membrane]
(Saccharomyces cerevisiae)
GNA13 [plasma membrane]
(Schizosaccharomyces pombe)
GNA13 [plasma membrane]
(Sus scrofa)
gna13a [plasma membrane]
(Danio rerio)
G-protein alpha 13 [plasma membrane]
(Mus musculus)
gna13 [plasma membrane]
(Xenopus tropicalis)
Homologues of GNA13 [plasma membrane]
(Dictyostelium discoideum)
gbqA [plasma membrane]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_006563.2
,
NP_001269354.1
OpenTargets
ENSG00000120063
GeneCards
Q14344
HPA
ENSG00000120063-GNA13
Ensembl
ENST00000439174
,
ENSG00000120063
,
ENSP00000439647
,
ENST00000541118
,
ENSP00000400717
PRO
Q14344
Pharos - Targets
Q14344
HMDB Protein
HMDBP11478
PDB
7T6B
,
7YDH
,
7SF7
,
7SF8
,
8H8J
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q92888 ARHGEF1
1
ARHGEF1 [cytosol]
(R-HSA-114526)
0.564
3
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