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POU2F1 [nucleoplasm]
Stable Identifier
R-HSA-83836
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Oct-1, POU domain, class 2, transcription factor 1, Octamer-binding transcription factor 1, OTF-1, NF-A1
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
RNA polymerase II transcribes snRNA genes (Homo sapiens)
CBCAP complex binds 7-methylguanosine cap of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
Dephosphorylation and dissociation of RNA polymerase II at 3' end of snRNA gene (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
Integrator complex processes the 3' end of snRNA (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
POU2F1 (OCT1) or POU2F2 (OCT2), SP1, and ZNF143 (STAF) bind the DSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
Pre-snRNA is elongated and capped with 7-methylguanosine (Homo sapiens)
RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
Pre-snRNA transcript initiation, Integrator binding, LEC binding (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Homo sapiens)
RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Homo sapiens)
Initiation factors:CDK7:snRNA gene [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
SNAPc binds PSE of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA Polymerase III Transcription (Homo sapiens)
RNA Polymerase III Abortive And Retractive Initiation (Homo sapiens)
RNA Polymerase III Abortive Initiation At Type 3 Open Promoters (Homo sapiens)
RNA Polymerase III:TFIIIB:SNAPc:Type 3 Open Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA Polymerase III Promoter Opening at Type 3 Promoters (Homo sapiens)
RNA Polymerase III:TFIIIB:SNAPc:Type 3 Open Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA Polymerase III:TFIIIB:SNAPc:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters (Homo sapiens)
RNA Polymerase III:TFIIIB:SNAPc:Type 3 Open Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA Polymerase III Transcription Initiation (Homo sapiens)
RNA Polymerase III Transcription Initiation From Type 3 Promoter (Homo sapiens)
Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Homo sapiens)
SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA Polymerase III Promoter Opening at Type 3 Promoters (Homo sapiens)
RNA Polymerase III:TFIIIB:SNAPc:Type 3 Open Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
RNA Polymerase III:TFIIIB:SNAPc:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Homo sapiens)
RNA Polymerase III:TFIIIB:SNAPc:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Nuclear Receptors (Homo sapiens)
ESR-mediated signaling (Homo sapiens)
Estrogen-dependent gene expression (Homo sapiens)
Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
Estrogen-responsive CCND1 gene expression (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Homo sapiens)
POU2F1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14859 POU2F1
Gene Names
POU2F1, OCT1, OTF1
Chain
chain:1-743
Reference Genes
COSMIC (genes):POU2F1 POU2F1
dbSNP Gene:5451 POU2F1
ENSEMBL:ENSG00000143190 POU2F1
Participates
as a member of
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
POU2F1,2 [nucleoplasm] (Homo sapiens)
as an input of
Binding of SNAPc, Oct-1, and Staf to Type 3 Promoter (Homo sapiens)
Binding of AP1 transcriptional activator complexes to CCND1 promoter (Homo sapiens)
as a component of
SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Homo sapiens)
RNA Polymerase III:TFIIIB:SNAPc:Type 3 Open Promoter Complex [nucleoplasm] (Homo sapiens)
CCND1 gene:H3K4me2 nucleosome:FOXA1:GATA3:ESTG:ESR1 dimer:JUN:ATF2:POUF21:ESTG:ESR1 dimer:JUN:FOS [nucleoplasm] (Homo sapiens)
Inferred To
pou2f1 [nucleoplasm]
(Xenopus tropicalis)
nub [nucleoplasm]
(Drosophila melanogaster)
POU2F1 [nucleoplasm]
(Bos taurus)
POU2F1 [nucleoplasm]
(Canis familiaris)
POU2F1 [nucleoplasm]
(Gallus gallus)
POU2F1 [nucleoplasm]
(Sus scrofa)
Pou2f1 [nucleoplasm]
(Mus musculus)
Pou2f1 [nucleoplasm]
(Rattus norvegicus)
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08047 SP1
1
SP1 [nucleoplasm]
(R-HSA-1592223)
0.725
7
UniProt:Q02446 SP4
0.556
5
UniProt:Q7Z3K3 POGZ
0.556
3
UniProt:Q9H4B4 PLK3
1
PLK3 [nucleoplasm]
(R-HSA-3222161)
0.556
3
UniProt:P14859 POU2F1
1
POU2F1 [nucleoplasm]
(R-HSA-83836)
0.553
2
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