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PLK3 [nucleoplasm]
Stable Identifier
R-HSA-3222161
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Serine/threonine-protein kinase PLK3, Cytokine-inducible serine/threonine-protein kinase, FGF-inducible kinase, Polo-like kinase 3, PLK-3, Proliferation-related kinase, CNK, FNK, PRK
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Phosphorylation (Homo sapiens)
PLK3 phosphorylates TP53 (Homo sapiens)
PLK3 [nucleoplasm] (Homo sapiens)
TP53 Regulates Transcription of Cell Cycle Genes (Homo sapiens)
TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain (Homo sapiens)
PLK3 phosphorylates CDC25C (Homo sapiens)
PLK3 [nucleoplasm] (Homo sapiens)
TP53 stimulates PLK3 expression (Homo sapiens)
PLK3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H4B4 PLK3
Gene Names
PLK3, CNK, FNK, PRK
Chain
chain:1-646
Reference Genes
BioGPS Gene:1263 PLK3
COSMIC (genes):PLK3 PLK3
CTD Gene:1263 PLK3
dbSNP Gene:1263 PLK3
ENSEMBL:ENSG00000173846 PLK3
HGNC:2154 PLK3
KEGG Gene (Homo sapiens):1263 PLK3
Monarch:1263 PLK3
NCBI Gene:1263 PLK3
OMIM:602913 PLK3
UCSC:Q9H4B4 PLK3
Reference Transcript
RefSeq:NM_004073.3 PLK3
Other Identifiers
0007050022
11756358_a_at
1263
16664005
204958_at
2334192
2334193
2334194
2334195
2334196
2334197
2334198
2334199
2334200
2334202
2334203
2334205
2334206
2334207
2334209
2334211
2334213
2334214
7901054
806_at
A_14_P100293
GE59249
GO:0000082
GO:0000086
GO:0000122
GO:0000166
GO:0000278
GO:0000302
GO:0000922
GO:0002039
GO:0003674
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005794
GO:0005795
GO:0005813
GO:0005815
GO:0005856
GO:0006464
GO:0006468
GO:0006810
GO:0006914
GO:0006915
GO:0006950
GO:0006970
GO:0006974
GO:0006977
GO:0007010
GO:0007049
GO:0007093
GO:0007113
GO:0007165
GO:0008150
GO:0008219
GO:0009056
GO:0009058
GO:0009314
GO:0015031
GO:0016301
GO:0016310
GO:0016740
GO:0030425
GO:0031122
GO:0032465
GO:0034641
GO:0043025
GO:0043066
GO:0043167
GO:0043226
GO:0043491
GO:0044819
GO:0051301
GO:0051302
GO:0090166
GO:0090316
GO:1901796
GO:1904716
GO:2000777
ILMN_1679979
PH_hs_0009238
PH_hs_0039402
TC01000566.hg
U56998_at
g4758015_3p_at
Participant Of
output
TP53 stimulates PLK3 expression
Inferred To
plo1 [nucleoplasm] (Schizosaccharomyces pombe)
PLK [nucleoplasm] (Dictyostelium discoideum)
Plk3 [nucleoplasm] (Mus musculus)
Plk3 [nucleoplasm] (Rattus norvegicus)
rab11fip4l [nucleoplasm] (Xenopus tropicalis)
plk3 [nucleoplasm] (Danio rerio)
cbfB [nucleoplasm] (Dictyostelium discoideum)
CDC5 [nucleoplasm] (Saccharomyces cerevisiae)
PLK3 [nucleoplasm] (Bos taurus)
PLK3 [nucleoplasm] (Canis familiaris)
PLK3 [nucleoplasm] (Sus scrofa)
Homologues of PLK3 [nucleoplasm] (Dictyostelium discoideum)
Cross References
RefSeq
NP_004064.2
ZINC - World Drugs
PLK3_HUMAN
OpenTargets
ENSG00000173846
ZINC - FDA approved
PLK3_HUMAN
ZINC - Substances
PLK3_HUMAN
ZINC target
Q9H4B4
ZINC - Biogenic
PLK3_HUMAN
PRO
Q9H4B4
PDB
4B6L
ZINC - Investigational
PLK3_HUMAN
HPA
ENSG00000173846-PLK3
GeneCards
Q9H4B4
Ensembl
ENST00000372201
,
ENSG00000173846
,
ENSP00000361275
ZINC - Predictions - Purchasable
PLK3_HUMAN
HMDB Protein
HMDBP01332
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99986 VRK1
2
VRK1 [nucleoplasm]
(R-HSA-2528998)
VRK1 [cytosol]
(R-HSA-2995381)
0.65
12
UniProt:P04156 PRNP
2
PRNP [plasma membrane]
(R-HSA-375060)
PRNP [cytosol]
(R-HSA-9617597)
0.571
4
UniProt:Q9GZY8-5 MFF
0.556
3
UniProt:P43351 RAD52
3
RAD52 [nucleoplasm]
(R-HSA-62639)
SUMO1-K411,K412,K414-RAD52 [nucleoplasm]
(R-HSA-4568909)
p-Y104-RAD52 [nucleoplasm]
(R-HSA-5686588)
0.556
3
UniProt:Q8WVD5 RN141
0.556
3
UniProt:Q9Y4Y9 LSM5
2
LSM5 [nucleoplasm]
(R-HSA-6806795)
LSM5 [cytosol]
(R-HSA-429839)
0.556
3
UniProt:P14859 POU2F1
1
POU2F1 [nucleoplasm]
(R-HSA-83836)
0.556
3
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