Reactome | Pou2f1 [nucleoplasm]

Pou2f1 [nucleoplasm]

Stable Identifier

R-MMU-83836

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

POU2F1, P25425

Locations in the PathwayBrowser

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Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - RNA polymerase II transcribes snRNA genes (Mus musculus)
    - CBCAP complex binds 7-methylguanosine cap of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
    - CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
    - General transcription factors bind SNAPc:POU2F1:ZNF143:snRNA gene (Mus musculus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
      - SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
    - Integrator complex processes the 3' end of snRNA (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:CBCAP:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
    - Pre-snRNA is elongated and capped with 7-methylguanosine (Mus musculus)
      - RNA polymerase II (phosphoserine-2,7):RPAP2:Integrator:LEC:capped pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
    - Pre-snRNA transcript initiation, Integrator binding, LEC binding (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):RPRD1A,B:RPRD2:RPAP2:Integrator:LEC:pre-snRNA:Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
    - RNA polymerase II binds initiation factors at promoter of snRNA gene (U1, U2, U4, U4atac, U5, U11, U12) (Mus musculus)
      - Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
      - RNA polymerase II (unphosphorylated):Initiation factors at promoter of snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
    - RPAP2 binds RNA polymerase II phosphorylated at serine-7 residues of heptad repeats in the C-terminal domain (Mus musculus)
      - RNA polymerase II (phosphoserine-5,7):Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
      - RPAP2:RPRD1A,B:RPRD2:RNA polymerase II (phosphoserine-5,7):Initiation factors:snRNA gene [nucleoplasm] (Mus musculus)
        
        Initiation factors:CDK7:snRNA gene [nucleoplasm] (Mus musculus)
        
        SNAPc:POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2:SP1:ZNF143:snRNA gene [nucleoplasm] (Mus musculus)
        
        POU2F1,2 [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
- RNA Polymerase III Transcription (Mus musculus)
  - RNA Polymerase III Transcription Initiation (Mus musculus)
    - RNA Polymerase III Transcription Initiation From Type 3 Promoter (Mus musculus)
      - Binding of TFIIIB to SNAPc:Oct-1:Staf:Type 3 Promoter Complex (Mus musculus)
        
        SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
        
        TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Mus musculus)
        
        SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
      - Recruitment of RNA Polymerase III to TFIIIB:SNAPc:Type 3 Promoter Complex (Mus musculus)
        
        RNA Polymerase III:TFIIIB:SNAPc:Type 3 Promoter Complex [nucleoplasm] (Mus musculus)
        
        TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Mus musculus)
        
        SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)
        
        TFIIIB:SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Mus musculus)
        
        SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Mus musculus)
        
        Pou2f1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:P25425

Gene Names

Pou2f1

Reference Genes

BioGPS Gene:18986 Pou2f1

ENSEMBL:ENSMUSG00000026565

ENSEMBL:ENSMUSG00000026565.19 Pou2f1

KEGG Gene (Mus musculus):18986 Pou2f1

Monarch:18986 Pou2f1

NCBI Gene:18986 Pou2f1

UCSC:P25425 Pou2f1

Reference Transcript

Other Identifiers

102893_at

102894_g_at

10359770

1419716_a_at

1427695_a_at

17229282

18986

4332662

4425985

4447834

4517708

4546943

4627483

4667924

4836785

4857998

4945539

4985531

4999289

5086137

5166918

5189305

5259059

5277641

5303168

5408096

5409391

5454951

5483143

5503905

5563875

5575890

A_51_P361492

A_52_P313246

A_55_P2209912

A_55_P2741213

GE35922

GO:0000976

GO:0000978

GO:0000979

GO:0000981

GO:0003677

GO:0003682

GO:0003700

GO:0005102

GO:0005515

GO:0005634

GO:0005654

GO:0005667

GO:0005783

GO:0006351

GO:0006355

GO:0006357

GO:0006366

GO:0010629

GO:0030910

GO:0042802

GO:0043226

GO:0043231

GO:0043565

GO:0045892

GO:0045944

GO:0048856

GO:0060235

GO:0090575

GO:0140110

ILMN_2609097

ILMN_2663366

ILMN_2663367

ILMN_3127178

mMR001198

x70325_s_at

Participates

as a component of

SNAPc:Oct-1:Staf:Type 3 Promoter Complex [nucleoplasm] (Mus musculus)

as a member of

POU2F1,2 [nucleoplasm] (Mus musculus)

Inferred From

POU2F1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_035267.2, NP_945151.2, XP_017174849.1, XP_011237069.1, XP_006496767.1, XP_011237071.1

Ensembl

ENSMUSP00000107057, ENSMUST00000184643, ENSMUST00000111429, ENSMUSG00000026565, ENSMUSP00000138962, ENSMUST00000069609, ENSMUSP00000064000

PRO

P25425

MGI

101898

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