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EIF4H [cytosol]
Stable Identifier
R-HSA-72591
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4H, eIF-4H, eukaryotic translation initiation factor 4H, Williams-Beuren syndrome chromosome region 1 protein, Eukaryotic translation initiation factor 4H
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15056 EIF4H
Gene Names
EIF4H, KIAA0038, WBSCR1, WSCR1
Chain
initiator methionine:, chain:2-248
Reference Genes
BioGPS Gene:7458 EIF4H
COSMIC (genes):EIF4H EIF4H
CTD Gene:7458 EIF4H
dbSNP Gene:7458 EIF4H
ENSEMBL:ENSG00000106682 EIF4H
HGNC:12741 EIF4H
KEGG:hsa:7458 EIF4H
Monarch:7458 EIF4H
NCBI Gene:7458 EIF4H
OMIM:603431 EIF4H
UCSC:Q15056 EIF4H
Reference Transcript
RefSeq:NM_031992.1 EIF4H
RefSeq:NM_022170.1 EIF4H
Participates
as an output of
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
as a component of
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
as an input of
Cap-bound mRNA is activated by helicases (Homo sapiens)
Inferred To
NOP13 [cytosol]
(Saccharomyces cerevisiae)
drr-2 [cytosol]
(Caenorhabditis elegans)
EIF4H [cytosol]
(Bos taurus)
EIF4H [cytosol]
(Canis familiaris)
EIF4H [cytosol]
(Gallus gallus)
EIF4H [cytosol]
(Plasmodium falciparum)
EIF4H [cytosol]
(Sus scrofa)
Eif4h [cytosol]
(Mus musculus)
Eif4h [cytosol]
(Rattus norvegicus)
eif4h [cytosol]
(Xenopus tropicalis)
sce3 [cytosol]
(Schizosaccharomyces pombe)
Homologues of EIF4H [cytosol]
(Saccharomyces cerevisiae)
TIF3 [cytosol]
(Saccharomyces cerevisiae)
Ghost homologue of EIF4H [cytosol]
(Danio rerio)
Ghost homologue of EIF4H [cytosol]
(Dictyostelium discoideum)
eIF4H1 [cytosol]
(Drosophila melanogaster)
Cross References
ENSEMBL
ENST00000678438
,
ENSG00000106682
,
ENST00000265753
,
ENSP00000265753
,
ENSP00000265754
,
ENST00000353999
,
ENSP00000504679
OpenTargets
ENSG00000106682
GeneCards
EIF4H
HPA
ENSG00000106682-EIF4H
PRO
Q15056
Pharos - Targets
Q15056
GlyGen
Q15056
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H3H3 CK068
0.742
5
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.666
4
UniProt:P0DTD1-PRO_0000449627 REP
0.643
3
UniProt:P60842 EIF4A1
1
EIF4A1 [cytosol]
(R-HSA-72573)
0.544
2
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