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EIF4H [cytosol]
Stable Identifier
R-HSA-72591
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
eIF4H, eIF-4H, eukaryotic translation initiation factor 4H, Williams-Beuren syndrome chromosome region 1 protein, Eukaryotic translation initiation factor 4H
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Translation (Homo sapiens)
Eukaryotic Translation Initiation (Homo sapiens)
Cap-dependent Translation Initiation (Homo sapiens)
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S (Homo sapiens)
Cap-bound mRNA is activated by helicases (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Translation initiation complex formation (Homo sapiens)
Formation of translation initiation complexes containing mRNA that does not circularize (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Formation of translation initiation complexes yielding circularized Ceruloplasmin mRNA in a 'closed-loop' conformation (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
GTP hydrolysis and joining of the 60S ribosomal subunit (Homo sapiens)
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Ribosomal scanning and start codon recognition (Homo sapiens)
Ribosomal scanning (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
Start codon recognition (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
L13a-mediated translational silencing of Ceruloplasmin expression (Homo sapiens)
Association of phospho-L13a with GAIT element of Ceruloplasmin mRNA (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
phospho-L13a associated wth the 3' UTR GAIT element of ceruloplasmin mRNA within the translation initiation complex [cytosol] (Homo sapiens)
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
EIF4H [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15056 EIF4H
Gene Names
EIF4H, KIAA0038, WBSCR1, WSCR1
Chain
initiator methionine:1, chain:2-248
Reference Genes
BioGPS Gene:7458 EIF4H
COSMIC (genes):EIF4H EIF4H
CTD Gene:7458 EIF4H
dbSNP Gene:7458 EIF4H
ENSEMBL:ENSG00000106682.16 EIF4H
HGNC:12741 EIF4H
KEGG Gene (Homo sapiens):7458 EIF4H
Monarch:7458 EIF4H
NCBI Gene:7458 EIF4H
OMIM:603431 EIF4H
UCSC:Q15056 EIF4H
Reference Transcript
RefSeq:NM_022170.1 EIF4H
RefSeq:NM_031992.1 EIF4H
Other Identifiers
11750029_a_at
11757778_s_at
17047073
17124692
206621_3p_s_at
206621_PM_s_at
206621_s_at
3008145
3008146
3008150
3008152
3008153
3008154
3008157
3008158
3008159
3043128
3043129
3043130
3043131
3043132
41212_r_at
55223_at
7458
8133434
8138773
A_21_P0013292
A_24_P149390
A_24_P720202
D26068_at
GE61245
GO:0001731
GO:0002181
GO:0003676
GO:0003723
GO:0003743
GO:0005515
GO:0005737
GO:0005829
GO:0006412
GO:0006413
GO:0006446
GO:0008135
GO:0016020
GO:0016281
GO:0019953
GO:0033592
GO:0034057
GO:0043024
GO:0045182
GO:0045296
GO:0048471
GO:0048589
GO:0065003
GO:0097010
HMNXSV003040685
ILMN_1729832
ILMN_1737586
ILMN_1776021
ILMN_2304624
PH_hs_0027944
TC07000451.hg
TC07002860.hg
g11559922_3p_a_at
g11559922_3p_x_at
Participates
as a component of
43S: Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H:PABP [cytosol] (Homo sapiens)
Ceruloplasmin mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
43S:mRNA:eIF4F:eIF4B:eIF4H [cytosol] (Homo sapiens)
48S complex [cytosol] (Homo sapiens)
as an input of
Cap-bound mRNA is activated by helicases (Homo sapiens)
as an output of
eIF2:GTP is hydrolyzed, eIFs are released (Homo sapiens)
Inferred To
NOP13 [cytosol]
(Saccharomyces cerevisiae)
drr-2 [cytosol]
(Caenorhabditis elegans)
EIF4H [cytosol]
(Bos taurus)
EIF4H [cytosol]
(Canis familiaris)
EIF4H [cytosol]
(Danio rerio)
EIF4H [cytosol]
(Gallus gallus)
EIF4H [cytosol]
(Sus scrofa)
Eif4h [cytosol]
(Mus musculus)
Eif4h [cytosol]
(Rattus norvegicus)
eif4h [cytosol]
(Xenopus tropicalis)
Ghost homologue of EIF4H [cytosol]
(Dictyostelium discoideum)
Ghost homologue of EIF4H [cytosol]
(Plasmodium falciparum)
Ghost homologue of EIF4H [cytosol]
(Schizosaccharomyces pombe)
eIF4H1 [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_114381.1
,
NP_071496.1
OpenTargets
ENSG00000106682
GeneCards
Q15056
HPA
ENSG00000106682-EIF4H
Ensembl
ENST00000678438
,
ENST00000353999
,
ENST00000265753
,
ENSP00000265753
,
ENSP00000265754
,
ENSG00000106682
,
ENSP00000504679
PRO
Q15056
Pharos - Targets
Q15056
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H3H3 CK068
0.742
5
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.666
4
UniProt:P0DTD1-PRO_0000449627 REP
0.643
3
UniProt:P60842 EIF4A1
1
EIF4A1 [cytosol]
(R-HSA-72573)
0.544
2
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