Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate

Stable Identifier
R-HSA-70501
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
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Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate
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The carboxylation of pyruvate to form oxaloacetate, catalyzed by mitochondrial pyruvate carboxylase, is an irreversible and allosterically regulated reaction (Jitrapakdee and Wallace 1999).

Literature References
PubMed ID Title Journal Year
12437512 Expression and characterization of a human pyruvate carboxylase variant by retroviral gene transfer

Robinson, BH, Carbone, MA

Biochem J 2003
Participants
Input
Output
Participates
as an event of
Catalyst Activity

pyruvate carboxylase activity of pyruvate carboxylase holoenzyme [mitochondrial matrix]

Physical Entity
pyruvate carboxylase holoenzyme [mitochondrial matrix] (Homo sapiens)
Activity
pyruvate carboxylase activity (GO:0004736)
This event is regulated
Positively by
Regulator
Ac-CoA [mitochondrial matrix]
Orthologous Events
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Caenorhabditis elegans)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Canis familiaris)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Danio rerio)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Drosophila melanogaster)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Mus musculus)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Rattus norvegicus)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Saccharomyces cerevisiae)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Schizosaccharomyces pombe)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Sus scrofa)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Xenopus tropicalis)
Reviewed
Harris, RA  (2008-09-10)
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