Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate

Stable Identifier
R-HSA-70501
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
Pyruvate, CO2, and ATP react to form oxaloacetate, ADP, and orthophosphate
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Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate
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The carboxylation of pyruvate to form oxaloacetate, catalyzed by mitochondrial pyruvate carboxylase, is an irreversible and allosterically regulated reaction (Jitrapakdee and Wallace 1999).

Literature References
PubMed ID Title Journal Year
12437512 Expression and characterization of a human pyruvate carboxylase variant by retroviral gene transfer

Carbone, MA, Robinson, BH

Biochem J 2003
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
pyruvate carboxylase activity of pyruvate carboxylase holoenzyme [mitochondrial matrix]
Physical Entity
pyruvate carboxylase holoenzyme [mitochondrial matrix]
Activity
pyruvate carboxylase activity (0004736)
This event is regulated
Positively by
Orthologous Events
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Bos taurus)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Caenorhabditis elegans)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Canis familiaris)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Danio rerio)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Drosophila melanogaster)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Mus musculus)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Rattus norvegicus)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Saccharomyces cerevisiae)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Schizosaccharomyces pombe)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Sus scrofa)
Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate (Xenopus tropicalis)
Reviewed
Harris, RA  (2008-09-10)