Reactome | Glycerophospholipid catabolism

Glycerophospholipid catabolism

Stable Identifier

R-HSA-6814848

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Reactions grouped in this pathway because of their shared chemistry - the hydrolysis of various phosphatidyl inositols and related phospholipids. They differ, however, in the tissues in which they occur and in their likely physiological roles. The activities of PNPLA6 and GDPD5 annotated here, for example, are especially prominent in kidney cells where the choline they generate plays a role in protecting cells from osmotic stress (Burg et al. 2007). Expression of others may be correlated with specific developmental events (Corda et al. 2013).

Literature References

PubMed ID	Title	Journal	Year
17928589	Cellular response to hyperosmotic stresses Ferraris, JD, Dmitrieva, NI, Burg, MB	Physiol. Rev.	2007
24373430	The emerging physiological roles of the glycerophosphodiesterase family Corda, D, Mariggiò, S, Yanaka, Noriyuki, Grauso, L, Ohshima, N, Mosca, MG	FEBS J.	2014