GDPD1 hydrolyzes LysoPtdCho

Stable Identifier
R-HSA-6814766
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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GDPD1 (Glycerophosphodiester phosphodiesterase domain-containing protein 1, also known as GDE4 - Glycerophosphodiester phosphodiesterase 4) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The human protein has been characterized only to a limited extent; its enzymatic activity and predominant intracellular localization are inferred from in vitro studies of the recombinant homologous mouse protein (Oshima et al. 2015).

Literature References
PubMed ID Title Journal Year
25528375 New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity

Ohshima, N, Kudo, T, Yamashita, Y, Mariggi├▓, S, Araki, M, Honda, A, Nagano, T, Isaji, C, Kato, N, Corda, D, Izumi, T, Yanaka, Noriyuki

J. Biol. Chem. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lysophospholipase activity of GDPD1 [endoplasmic reticulum membrane]
Physical Entity
Activity
Inferred From
Authored
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