GDPD1 hydrolyzes LysoPtdCho

Stable Identifier
R-HSA-6814766
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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GDPD1 hydrolyzes LysoPtdCho
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GDPD1 (Glycerophosphodiester phosphodiesterase domain-containing protein 1, also known as GDE4 - Glycerophosphodiester phosphodiesterase 4) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The human protein has been characterized only to a limited extent; its enzymatic activity and predominant intracellular localization are inferred from in vitro studies of the recombinant homologous mouse protein (Oshima et al. 2015).
Literature References
PubMed ID Title Journal Year
25528375 New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity

Ohshima, N, Kudo, T, Yamashita, Y, Mariggiò, S, Araki, M, Honda, A, Nagano, T, Isaji, C, Kato, N, Corda, D, Izumi, T, Yanaka, Noriyuki

J. Biol. Chem. 2015
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Output
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as an event of
Catalyst Activity

phosphatidylcholine lysophospholipase A1 activity of GDPD1 [endoplasmic reticulum membrane]

Physical Entity
GDPD1 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
phosphatidylcholine lysophospholipase A1 activity (GO:0004622)
Inferred From
Gdpd1 hydrolyzes LysoPtdCho (Mus musculus)
Authored
D'Eustachio, P  (2015-11-28)
Reviewed
Jassal, B  (2015-11-30)
Created
D'Eustachio, P  (2015-11-27)
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