PNPLA7 hydrolyzes LysoPtdCho

Stable Identifier
R-HSA-8847912
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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PNPLA7 hydrolyzes LysoPtdCho
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PNPLA7 (Patatin-like phospholipase domain-containing protein 7, also known as NRE - NTE-related esterase) associated with the endoplasmic reticulum membrane catalyzes the hydrolysis of LysoPtcCho (lysophosphatidylcholine) to GPCho (glycerophosphocholine) and LCFA (long chain fatty acid). The human enzyme is expressed most abundantly in prostate, pancreas, and adipose tissues (Wilson et al. 2006). Its location and enzymatic activity have been inferrred from the properties of its mouse homologue (Kienesberger et al. 2008).

Literature References
PubMed ID Title Journal Year
18086666 Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase

Zimmermann, R, Kienesberger, PC, Kohlwein, SD, Wolinski, H, Preiss-Landl, K, Lass, A, Zechner, R

J. Biol. Chem. 2008
16799181 Characterization of the human patatin-like phospholipase family

Gardner, SD, Lambie, NM, Crowther, DJ, Wilson, PA, Commans, SA

J. Lipid Res. 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

lysophospholipase activity of PNPLA7 [endoplasmic reticulum membrane]

Physical Entity
PNPLA7 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
lysophospholipase activity (GO:0004622)
Inferred From
Pnpla7 hydrolyzes LysoPtdCho (Mus musculus)
Authored
D'Eustachio, P  (2015-12-03)
Reviewed
Jassal, B  (2015-11-30)
Created
D'Eustachio, P  (2015-12-03)
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