GDPD5 hydrolyzes GPCho

Stable Identifier
R-HSA-6814132
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum membrane, cytosol
ReviewStatus
5/5
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GDPD5 hydrolyzes GPCho
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GDPD5 (Glycerophosphodiester phosphodiesterase domain-containing protein 5; GDE2) catalyzes the hydrolysis of GPCho (glycero-3-phosphocholine) to G3P (glycerol-3-phosphate) and Cho (choline). The localization and activity of human GDPD5 are inferred from those of its better-characterized mouse homolog (Gallazzini et al. 2008).
Literature References
PubMed ID Title Journal Year
18667693 GDPD5 is a glycerophosphocholine phosphodiesterase that osmotically regulates the osmoprotective organic osmolyte GPC

Gallazzini, M, Ferraris, JD, Burg, MB

Proc. Natl. Acad. Sci. U.S.A. 2008
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Output
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Catalyst Activity

glycerophosphocholine phosphodiesterase activity of GDPD5 [endoplasmic reticulum membrane]

Physical Entity
GDPD5 [endoplasmic reticulum membrane] (Homo sapiens)
Activity
glycerophosphocholine phosphodiesterase activity (GO:0047389)
Inferred From
Gdpd5 hydrolyzes GPCho (Mus musculus)
Cross References
RHEA
Authored
D'Eustachio, P  (2015-11-28)
Reviewed
Jassal, B  (2015-11-30)
Created
D'Eustachio, P  (2015-11-25)
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